Lipid droplets in cancer: guardians of fat in a stressful world
T Petan, E Jarc, M Jusović - Molecules, 2018 - mdpi.com
Cancer cells possess remarkable abilities to adapt to adverse environmental conditions.
Their survival during severe nutrient and oxidative stress depends on their capacity to …
Their survival during severe nutrient and oxidative stress depends on their capacity to …
Lipid use and misuse by the heart
The heart utilizes large amounts of fatty acids as energy providing substrates. The
physiological balance of lipid uptake and oxidation prevents accumulation of excess lipids …
physiological balance of lipid uptake and oxidation prevents accumulation of excess lipids …
Metabolism in cardiomyopathy: every substrate matters
Cardiac metabolism is highly adaptive to changes in fuel availability and the energy demand
of the heart. This metabolic flexibility is key for the heart to maintain its output during the …
of the heart. This metabolic flexibility is key for the heart to maintain its output during the …
Obesity, diabetes, and cardiovascular diseases: a compendium
1704 Circulation Research May 27, 2016 of epigenetic mechanisms contributing to
macrovascular disease in diabetes. The authors highlight the recent identification of …
macrovascular disease in diabetes. The authors highlight the recent identification of …
Ventricular assist device implantation corrects myocardial lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart …
A Chokshi, K Drosatos, FH Cheema, R Ji, T Khawaja… - Circulation, 2012 - Am Heart Assoc
Background—Heart failure is associated with impaired myocardial metabolism with a shift
from fatty acids to glucose use for ATP generation. We hypothesized that cardiac …
from fatty acids to glucose use for ATP generation. We hypothesized that cardiac …
[HTML][HTML] Increased de novo ceramide synthesis and accumulation in failing myocardium
Abnormal lipid metabolism may contribute to myocardial injury and remodeling. To
determine whether accumulation of very long–chain ceramides occurs in human failing …
determine whether accumulation of very long–chain ceramides occurs in human failing …
The contribution of cardiac fatty acid oxidation to diabetic cardiomyopathy severity
Diabetes is a major risk factor for the development of cardiovascular disease via contributing
and/or triggering significant cellular signaling and metabolic and structural alterations at the …
and/or triggering significant cellular signaling and metabolic and structural alterations at the …
Cardiac lipotoxicity: molecular pathways and therapeutic implications
Diabetes and obesity are both associated with lipotoxic cardiomyopathy exclusive of
coronary artery disease and hypertension. Lipotoxicities have become a public health …
coronary artery disease and hypertension. Lipotoxicities have become a public health …
Lipotoxicity in obesity and diabetes-related cardiac dysfunction
Patients with type 2 diabetes (T2D) are at increased risk for cardiovascular diseases
including diabetic cardiomyopathy, which is ventricular dysfunction independent of …
including diabetic cardiomyopathy, which is ventricular dysfunction independent of …
The mechanisms underlying lipid resuscitation therapy
The experimental use of lipid emulsion for local anesthetic toxicity was originally identified in
1998. It was then translated to clinical practice in 2006 and expanded to drugs other than …
1998. It was then translated to clinical practice in 2006 and expanded to drugs other than …