The aging process is driven at the cellular level by random molecular damage that slowly
accumulates with age. Although cells possess mechanisms to repair or remove damage …

Insulin and insulin-like growth factor (IGF) receptors utilize common phosphoinositide 3-
kinase/Akt and Ras/extracellular signal-regulated kinase signaling pathways to mediate a …

The kinase mammalian target of rapamycin (mTOR) exists in two multiprotein complexes
(mTORC1 and mTORC2) and is a central regulator of growth and metabolism. Insulin …

Improved mechanistic understanding of biochemical networks is one of the driving ambitions
of Systems Biology. Computational modeling allows the integration of various sources of …

Systems biology and its usage of mathematical modeling to analyse biological data is
rapidly becoming an established approach to biology. A crucial advantage of this approach …

One of the main challenges in the development of mathematical and computational models
of biological systems is the precise estimation of parameter values. Understanding the …

Insulin and other hormones control target cells through a network of signal-mediating
molecules. Such networks are extremely complex due to multiple feedback loops in …

Type 2 diabetes is a metabolic disease that profoundly affects energy homeostasis. The
disease involves failure at several levels and subsystems and is characterized by insulin …

Much data in the scientific literature demonstrate a fundamental involvement of caveolae in
insulin action, although particular aspects remain matters of debate. The insulin receptor …

Background Mathematical modeling is often used to formalize hypotheses on how a
biochemical network operates by discriminating between competing models. Bayesian …