Measuring biological age using omics data
Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …
related diseases and increase healthspan have suggested targeting the ageing process …
Validation of biomarkers of aging
The search for biomarkers that quantify biological aging (particularly 'omic'-based
biomarkers) has intensified in recent years. Such biomarkers could predict aging-related …
biomarkers) has intensified in recent years. Such biomarkers could predict aging-related …
[HTML][HTML] A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration
Aging involves a diverse set of biological changes accumulating over time that leads to
increased risk of morbidity and mortality. Epigenetic clocks are now widely used to quantify …
increased risk of morbidity and mortality. Epigenetic clocks are now widely used to quantify …
[HTML][HTML] Why does COVID-19 disproportionately affect older people?
The severity and outcome of coronavirus disease 2019 (COVID-19) largely depends on a
patient's age. Adults over 65 years of age represent 80% of hospitalizations and have a 23 …
patient's age. Adults over 65 years of age represent 80% of hospitalizations and have a 23 …
DNA methylation aging clocks: challenges and recommendations
Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
[HTML][HTML] DNA methylation GrimAge strongly predicts lifespan and healthspan
AT Lu, A Quach, JG Wilson, AP Reiner, A Aviv… - Aging (albany …, 2019 - ncbi.nlm.nih.gov
It was unknown whether plasma protein levels can be estimated based on DNA methylation
(DNAm) levels, and if so, how the resulting surrogates can be consolidated into a powerful …
(DNAm) levels, and if so, how the resulting surrogates can be consolidated into a powerful …
Diethyl ether as self-healing electrolyte additive enabled long-life rechargeable aqueous zinc ion batteries
Aqueous rechargeable zinc ion batteries (ARZIBs) is considered one of the most compelling
candidates for grid-scale energy storage owing to their cost effectiveness, good safety, eco …
candidates for grid-scale energy storage owing to their cost effectiveness, good safety, eco …
[HTML][HTML] An epigenetic biomarker of aging for lifespan and healthspan
Identifying reliable biomarkers of aging is a major goal in geroscience. While the first
generation of epigenetic biomarkers of aging were developed using chronological age as a …
generation of epigenetic biomarkers of aging were developed using chronological age as a …
[HTML][HTML] DNA methylation GrimAge version 2
We previously described a DNA methylation (DNAm) based biomarker of human mortality
risk DNAm GrimAge. Here we describe version 2 of GrimAge (trained on individuals aged …
risk DNAm GrimAge. Here we describe version 2 of GrimAge (trained on individuals aged …
A computational solution for bolstering reliability of epigenetic clocks: Implications for clinical trials and longitudinal tracking
Epigenetic clocks are widely used aging biomarkers calculated from DNA methylation data,
but this data can be surprisingly unreliable. Here we show that technical noise produces …
but this data can be surprisingly unreliable. Here we show that technical noise produces …