▪ Abstract The T cell antigen receptor (TCR) regulates the activation and growth of T
lymphocytes. The initial membrane proximal event triggered by the TCR is activation of …

Protein kinase C molecules regulate both positive and negative signal transduction
pathways essential for the initiation and homeostasis of immune responses. There are …

Cell cycle progression initiated by interleukin-2 (IL-2) in T cells is critical for
lymphoproliferation and an immune response. Phosphatidyl inositol 3-kinase (PI3K) is …

The central role of Ca 2+ signaling in the development of functional immunity and tolerance
is well established. These signals are initiated by antigen binding to cognate receptors on …

▪ Abstract Studies performed during the past several years make plain that ligand occupancy
of antigen receptors need not necessarily provoke identical responses in all instances. For …

The transcription factor, Nuclear Factor of Activated T cells (NFAT) is a major target for
p21ras and calcium signalling pathways in the IL‐2 gene and is induced by p21ras signals …

Protein kinase Cs (PKCs) are activated by antigen receptors in lymphocytes, but little is
known about proximal targets for PKCs in antigen receptor–mediated responses. In this …

Phospholipase Cγ2 (PLCγ2) plays a critical role in the functions of the B cell receptor in B
cells and of the FcRγ chain-containing collagen receptor in platelets. Here we report that …

Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) expression is associated with the
lymphoid malignancy anaplastic large cell lymphoma (ALCL) and results from at (2; 5) …

The Rho family of small GTP-binding proteins is involved in the regulation of cytoskeletal
structure, gene transcription, specific cell fate development, and transformation. We …