Acetylcholine (ACh) neurotransmitter of the cholinergic system in the brain is involved in
learning, memory, stress responses, and cognitive functioning. It is hydrolyzed into choline …

Recently, there has been increased microbial and multidrug resistance in clinical field that
negatively affects health because it leads to a variety of diseases due to inefficient mode of …

The reaction of BSP benzothiazol-2-yl-(4, 6-dimethyl-1H-pyrimidin-2-ylidene)-amine with Fe
3+, Ni 2+ and Pd 2+ resulted into three novel complexes. The ligand and metal complexes' …

Palladium-catalyzed Wacker-type reactions occupy a central place in organic synthesis with
important implications in industry. Pursuing more benign protocols by replacing palladium …

The direct C3 alkylation of indoles and oxindoles is a challenging transformation, and only a
few direct methods exist. Utilizing the underexplored ability of triaryl boranes to mediate the …

The development of drug resistance and severe side-effects has reduced the clinical efficacy
of the existing anti-cancer drugs available in the market. Thus, there is always a constant …

The fungal cytochrome P450 enzyme sterol 14α-demethylase (SDM) is a key enzyme in the
ergosterol biosynthesis pathway. The binding of azoles to the active site of SDM results in a …

Our goal was the evaluation of a series of N-1, 2, 3-triazole-isatin derivatives for multi-target
activity which included cholinesterase (ChE) inhibition and β-amyloid (Aβ) peptide anti …

Epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) are crucial
targetable enzymes in cancer management. Therefore, herein, new 2-[(5-((1 H-indol-3-yl) …

Racemic 3‐substituted oxindoles were successfully converted into enantiomerically pure or
enriched material (up to 99% ee) upon irradiation at λ= 366 nm in the presence of a chiral …