Sepsis occurs when an infection exceeds local tissue containment and induces a series of
dysregulated physiologic responses that result in organ dysfunction. A subset of patients …

Sepsis is a systemic inflammatory response induced by an infection, leading to organ
dysfunction and mortality. Historically, sepsis-induced organ dysfunction and lethality were …

Surgical intensive care unit (ICU) stay of longer than 10 days is often described by the
experienced intensivist as a “complicated clinical course” and is frequently attributed to …

Sepsis remains a major cause of death in the United States and worldwide, and costs
associated with treating septic patients place a large burden on the healthcare industry …

Sepsis results in a deluge of pro-and anti-inflammatory cytokines, leading to lymphopenia
and chronic immunoparalysis. Sepsis-induced long-lasting immunoparalysis is defined, in …

Polymicrobial sepsis alters the adaptive immune response and induces T cell suppression
and Th2 immune polarization. We identify a GR-1+ CD11b+ population whose numbers …

Sepsis is a syndrome of shock and dysfunction of multiple vital organs that is caused by an
uncontrolled immune response to infection and has a high mortality rate. There are no …

Implementation of protocolized surveillance, diagnosis, and management of septic patients,
and of surgical sepsis patients in particular, is shown to result in significantly increased …

Septic syndromes represent a major although largely underrecognized healthcare problem
worldwide, accounting for thousands of deaths every year. It is now agreed that sepsis …

Purpose Sepsis syndrome represents the leading cause of death in intensive care unit.
Patients present features consistent with a decline in immune responsiveness potentially …