Opportunities and challenges in the delivery of mRNA-based vaccines
In the past few years, there has been increasing focus on the use of messenger RNA
(mRNA) as a new therapeutic modality. Current clinical efforts encompassing mRNA-based …
(mRNA) as a new therapeutic modality. Current clinical efforts encompassing mRNA-based …
[HTML][HTML] Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development
E Larrañeta, REM Lutton, AD Woolfson… - Materials Science and …, 2016 - Elsevier
Transdermal drug delivery offers a number of advantages for the patient, due not only its non-
invasive and convenient nature, but also factors such as avoidance of first pass metabolism …
invasive and convenient nature, but also factors such as avoidance of first pass metabolism …
Microneedle system for tissue engineering and regenerative medicine
Global increasing demand for high life quality and length facilitates the development of
tissue engineering and regenerative medicine, which apply multidisciplinary theories and …
tissue engineering and regenerative medicine, which apply multidisciplinary theories and …
Recent advances of controlled drug delivery using microfluidic platforms
Conventional systematically-administered drugs distribute evenly throughout the body, get
degraded and excreted rapidly while crossing many biological barriers, leaving minimum …
degraded and excreted rapidly while crossing many biological barriers, leaving minimum …
Microneedle-based natural polysaccharide for drug delivery systems (DDS): progress and challenges
In this focused progress review, the most widely accepted methods of transdermal drug
delivery are hypodermic needles, transdermal patches and topical creams. However …
delivery are hypodermic needles, transdermal patches and topical creams. However …
Recent advancements in microneedle technology for multifaceted biomedical applications
Microneedle (MNs) technology is a recent advancement in biomedical science across the
globe. The current limitations of drug delivery, like poor absorption, low bioavailability …
globe. The current limitations of drug delivery, like poor absorption, low bioavailability …
Microneedles for intradermal and transdermal drug delivery
The formidable barrier properties of the uppermost layer of the skin, the stratum corneum,
impose significant limitations for successful systemic delivery of broad range of therapeutic …
impose significant limitations for successful systemic delivery of broad range of therapeutic …
Current advances in the fabrication of microneedles for transdermal delivery
The transdermal route is an excellent site for drug delivery due to the avoidance of gastric
degradation and hepatic metabolism, in addition to easy accessibility. Although offering …
degradation and hepatic metabolism, in addition to easy accessibility. Although offering …
Microneedles: a new frontier in nanomedicine delivery
This review aims to concisely chart the development of two individual research fields,
namely nanomedicines, with specific emphasis on nanoparticles (NP) and microparticles …
namely nanomedicines, with specific emphasis on nanoparticles (NP) and microparticles …
[HTML][HTML] Going beyond the liver: progress and challenges of targeted delivery of siRNA therapeutics
C Lorenzer, M Dirin, AM Winkler, V Baumann… - Journal of Controlled …, 2015 - Elsevier
Therapeutic gene silencing promises significant progress in pharmacotherapy, including
considerable expansion of the druggable target space and the possibility for treating orphan …
considerable expansion of the druggable target space and the possibility for treating orphan …