Lipases: Useful biocatalysts for the preparation of pharmaceuticals
Biocatalysis offers a clean and ecological way to perform chemical processes, in mild
reaction conditions and with high degree of selectivity. The use of enzymes, specially …
reaction conditions and with high degree of selectivity. The use of enzymes, specially …
Hydrolases in the Stereoselective Synthesis of N-Heterocyclic Amines and Amino Acid Derivatives
Chiral nitrogenated compounds are highly attractive compounds because of their
importance in agrochemicals, fine chemicals, and pharmaceuticals but also due to their …
importance in agrochemicals, fine chemicals, and pharmaceuticals but also due to their …
[ספר][B] Biotransformations in organic chemistry: a textbook
K Faber, K Faber - 2004 - Springer
The use of natural catalysts-enzymes-for the transformation of nonnatural man-made
organic compounds is not at all new: they have been used for more than one hundred years …
organic compounds is not at all new: they have been used for more than one hundred years …
Lipases: An overview of its current challenges and prospectives in the revolution of biocatalysis
Over the past few years most of the biochemical industries are in a rapid stage of
development. The major root cause responsible for this current state of excitement is a new …
development. The major root cause responsible for this current state of excitement is a new …
[ספר][B] Handbook of chiral chemicals
D Ager - 2005 - taylorfrancis.com
As pharmaceutical companies look to develop single enantiomers as drug candidates,
chemists are increasingly faced with the problems associated with this subclass of organic …
chemists are increasingly faced with the problems associated with this subclass of organic …
Recent advances in the stereoselective synthesis of trans-3, 4-disubstituted-piperidines: applications to (−)-paroxetine
Piperidine ring systems are the key structural elements in a vast array of natural products as
well as in a large class of biologically active natural products, being also often embedded …
well as in a large class of biologically active natural products, being also often embedded …
Synthesis of (−)-paroxetine via enantioselective phase-transfer catalytic monoalkylation of malonamide ester
A new enantioselective synthetic method of (−)-paroxetine is reported.(−)-Paroxetine could
be obtained in 15 steps (95% ee and 9.1% overall yield) from N, N-bis (p-methoxyphenyl) …
be obtained in 15 steps (95% ee and 9.1% overall yield) from N, N-bis (p-methoxyphenyl) …
Stereoselective enzymatic acylations (transesterifications)
R Chenevert, N Pelchat, F Jacques - Current Organic Chemistry, 2006 - benthamdirect.com
Hydrolytic enzymes such as lipases and esterases are the most frequently used biocatalysts
in organic synthesis. They have as their natural function, the hydrolysis of ester substrates in …
in organic synthesis. They have as their natural function, the hydrolysis of ester substrates in …
Stereospecific construction of substituted piperidines. Synthesis of (–)-paroxetine and (+)-laccarin
JF Bower, T Riis-Johannessen, P Szeto… - Chemical …, 2007 - pubs.rsc.org
Stereospecific construction of substituted piperidines . Synthesis of (–)-paroxetine and (+)-laccarin
- Chemical Communications (RSC Publishing) DOI:10.1039/B617260A Royal Society of …
- Chemical Communications (RSC Publishing) DOI:10.1039/B617260A Royal Society of …
Use of lipases in organic synthesis
The use of enzymes for organic synthesis has become an interesting area for organic and
bio-organic chemists. Since many enzymes have been demonstrated to possess activity …
bio-organic chemists. Since many enzymes have been demonstrated to possess activity …