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NRF2: KEA** tumors protected
The Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2–related factor 2
(NRF2) pathway plays a physiologic protective role against xenobiotics and reactive oxygen …
(NRF2) pathway plays a physiologic protective role against xenobiotics and reactive oxygen …
Carbon monoxide and its controlled release: therapeutic application, detection, and development of carbon monoxide releasing molecules (CORMs) miniperspective
K Ling, F Men, WC Wang, YQ Zhou… - Journal of Medicinal …, 2017 - ACS Publications
Carbon monoxide (CO) is attracting increasing attention because of its role as a
gasotransmitter with cytoprotective and homeostatic properties. Carbon monoxide releasing …
gasotransmitter with cytoprotective and homeostatic properties. Carbon monoxide releasing …
The therapeutic potential of carbon monoxide
Carbon monoxide (CO) is increasingly being accepted as a cytoprotective and homeostatic
molecule with important signalling capabilities in physiological and pathophysiological …
molecule with important signalling capabilities in physiological and pathophysiological …
Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation
SW Ryter, AMK Choi - Translational Research, 2016 - Elsevier
The heme oxygenase-1 (HO-1) enzyme system remains an attractive therapeutic target for
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …
Mechanisms of cell protection by heme oxygenase-1
Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into
equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive …
equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive …
Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications
SW Ryter, J Alam, AMK Choi - Physiological reviews, 2006 - journals.physiology.org
The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2),
catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (ie …
catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (ie …
Mechanisms of cell death in oxidative stress
SW Ryter, HP Kim, A Hoetzel, JW Park… - Antioxidants & redox …, 2007 - liebertpub.com
Reactive oxygen or nitrogen species (ROS/RNS) generated endogenously or in response to
environmental stress have long been implicated in tissue injury in the context of a variety of …
environmental stress have long been implicated in tissue injury in the context of a variety of …
Carbon monoxide: endogenous production, physiological functions, and pharmacological applications
Over the last decade, studies have unraveled many aspects of endogenous production and
physiological functions of carbon monoxide (CO). The majority of endogenous CO is …
physiological functions of carbon monoxide (CO). The majority of endogenous CO is …
Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities
Carbon monoxide (CO) is generated in living organisms during the degradation of heme by
the enzyme heme oxygenase, which exists in constitutive (HO-2 and HO-3) and inducible …
the enzyme heme oxygenase, which exists in constitutive (HO-2 and HO-3) and inducible …
Biological signaling by carbon monoxide and carbon monoxide-releasing molecules
Carbon monoxide (CO) is continuously produced in mammalian cells during the
degradation of heme. It is a stable gaseous molecule that reacts selectively with transition …
degradation of heme. It is a stable gaseous molecule that reacts selectively with transition …