Intrinsically disordered proteins: an overview
Many proteins and protein segments cannot attain a single stable three-dimensional
structure under physiological conditions; instead, they adopt multiple interconverting …
structure under physiological conditions; instead, they adopt multiple interconverting …
Intrinsically disordered proteins in cellular signalling and regulation
PE Wright, HJ Dyson - Nature reviews Molecular cell biology, 2015 - nature.com
Intrinsically disordered proteins (IDPs) are important components of the cellular signalling
machinery, allowing the same polypeptide to undertake different interactions with different …
machinery, allowing the same polypeptide to undertake different interactions with different …
Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames
All species continuously evolve short open reading frames (sORFs) that can be templated
for protein synthesis and may provide raw materials for evolutionary adaptation. We …
for protein synthesis and may provide raw materials for evolutionary adaptation. We …
IUPred2A: context-dependent prediction of protein disorder as a function of redox state and protein binding
The structural states of proteins include ordered globular domains as well as intrinsically
disordered protein regions that exist as highly flexible conformational ensembles in …
disordered protein regions that exist as highly flexible conformational ensembles in …
A deep-learning framework for multi-level peptide–protein interaction prediction
Peptide-protein interactions are involved in various fundamental cellular functions and their
identification is crucial for designing efficacious peptide therapeutics. Recently, a number of …
identification is crucial for designing efficacious peptide therapeutics. Recently, a number of …
Pi-Pi contacts are an overlooked protein feature relevant to phase separation
Protein phase separation is implicated in formation of membraneless organelles, signaling
puncta and the nuclear pore. Multivalent interactions of modular binding domains and their …
puncta and the nuclear pore. Multivalent interactions of modular binding domains and their …
Extreme disorder in an ultrahigh-affinity protein complex
Molecular communication in biology is mediated by protein interactions. According to the
current paradigm, the specificity and affinity required for these interactions are encoded in …
current paradigm, the specificity and affinity required for these interactions are encoded in …
Phase separation of a yeast prion protein promotes cellular fitness
INTRODUCTION The formation of dynamic, membraneless compartments using intracellular
phase transitions such as phase separation and gelation provides an efficient way for cells …
phase transitions such as phase separation and gelation provides an efficient way for cells …
Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II
Hyperphosphorylation of the C-terminal domain (CTD) of the RPB1 subunit of human RNA
polymerase (Pol) II is essential for transcriptional elongation and mRNA processing,–. The …
polymerase (Pol) II is essential for transcriptional elongation and mRNA processing,–. The …
De novo birth of functional microproteins in the human lineage
Small open reading frames (sORFs) can encode functional" microproteins" that perform
crucial biological tasks. However, their size makes them less amenable to genomic analysis …
crucial biological tasks. However, their size makes them less amenable to genomic analysis …