Specialized peripheral sensory neurons known as nociceptors alert us to potentially
damaging stimuli at the skin by detecting extremes in temperature and pressure and injury …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a small
subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the …

The brain contains an astonishing diversity of neurons, each expressing only one set of ion
channels out of the billions of potential channel combinations. Simple organizing principles …

Life on Earth has been characterized by recurring cycles of ecological stasis and disruption,
relating biological eras to geological and climatic transitions through the history of our …

Voltage‐gated K+ channels (Kv) represent the largest family of genes in the K+ channel
family. The Kv1 subfamily plays an essential role in the initiation and sha** of action …

The Kv2 family of voltage-gated potassium channel α subunits, comprising Kv2. 1 and Kv2.
2, mediate the bulk of the neuronal delayed rectifier K+ current in many mammalian central …

How neuronal diversity emerges from complex patterns of gene expression remains poorly
understood. Here we present an approach to understand electrophysiological diversity …

Pain is a complex constellation of cognitive, unpleasant sensory, and emotional experiences
that primarily serves as a survival mechanism. Pain arises in the peripheral nervous system …

Simple Summary Glioblastoma multiforme is an aggressive grade IV lethal brain tumour with
a median survival of 14 months. Despite surgery to remove the tumour, and subsequent …

It is widely known that ion channels are expressed in the plasma membrane. However, a few
studies have suggested that several ion channels including voltage-gated K+(Kv) channels …