Chemometrics in metabonomics

J Trygg, E Holmes, T Lundstedt - Journal of proteome research, 2007 - ACS Publications
We provide an overview of how the underlying philosophy of chemometrics is integrated
throughout metabonomic studies. Four steps are demonstrated:(1) definition of the aim,(2) …

NMR and pattern recognition methods in metabolomics: from data acquisition to biomarker discovery: a review

A Smolinska, L Blanchet, LMC Buydens… - Analytica chimica …, 2012 - Elsevier
Metabolomics is the discipline where endogenous and exogenous metabolites are
assessed, identified and quantified in different biological samples. Metabolites are crucial …

Metabolomics-based methods for early disease diagnostics

GAN Gowda, S Zhang, H Gu, V Asiago… - Expert review of …, 2008 - Taylor & Francis
The emerging field of metabolomics, in which a large number of small-molecule metabolites
from body fluids or tissues are detected quantitatively in a single step, promises immense …

Chemometrics in metabolomics—a review in human disease diagnosis

R Madsen, T Lundstedt, J Trygg - Analytica chimica acta, 2010 - Elsevier
Metabolomics is a post genomic research field concerned with develo** methods for
analysis of low molecular weight compounds in biological systems, such as cells, organs or …

Targeted metabolomics for biomarker discovery

WJ Griffiths, T Koal, Y Wang, M Kohl… - Angewandte Chemie …, 2010 - Wiley Online Library
Metabolomics is a truly interdisciplinary field of science, which combines analytical
chemistry, platform technology, mass spectrometry, and NMR spectroscopy with …

NMR-based metabolomics in human disease diagnosis: applications, limitations, and recommendations

AHM Emwas, RM Salek, JL Griffin, J Merzaban - Metabolomics, 2013 - Springer
Metabolomics is a dynamic and emerging research field, similar to proteomics,
transcriptomics and genomics in affording global understanding of biological systems. It is …

Comparing and combining NMR spectroscopy and mass spectrometry in metabolomics

Z Pan, D Raftery - Analytical and bioanalytical chemistry, 2007 - Springer
The rapidly expanding field of metabolomics has been driven in recent years by advances in
the analytical methods of high-resolution nuclear magnetic resonance (NMR) spectroscopy …

Standardizing the experimental conditions for using urine in NMR-based metabolomic studies with a particular focus on diagnostic studies: a review

AH Emwas, C Luchinat, P Turano, L Tenori, R Roy… - Metabolomics, 2015 - Springer
The metabolic composition of human biofluids can provide important diagnostic and
prognostic information. Among the biofluids most commonly analyzed in metabolomic …

Normalization strategies for metabonomic analysis of urine samples

BM Warrack, S Hnatyshyn, KH Ott, MD Reily… - … of Chromatography B, 2009 - Elsevier
Unlike plasma and most biological fluids which have solute concentrations that are tightly
controlled, urine volume can vary widely based upon water consumption and other …

[HTML][HTML] The olive constituent oleuropein exhibits anti-ischemic, antioxidative, and hypolipidemic effects in anesthetized rabbits

I Andreadou, EK Iliodromitis, E Mikros… - The journal of …, 2006 - Elsevier
Thgoal of this study was to evaluate the efficacy of the antioxidant olive constituent,
oleuropein, on infarct size, oxidative damage, and the metabolic profile in rabbits subjected …