Endothelial dysfunction and platelet hyperactivity in type 2 diabetes mellitus: molecular insights and therapeutic strategies
The incidence and prevalence of diabetes mellitus is rapidly increasing worldwide at an
alarming rate. Type 2 diabetes mellitus (T2DM) is the most prevalent form of diabetes …
alarming rate. Type 2 diabetes mellitus (T2DM) is the most prevalent form of diabetes …
[HTML][HTML] The role of lipids and lipoproteins in atherosclerosis
MRF Linton, PG Yancey, SS Davies, WG Jerome… - Endotext …, 2019 - ncbi.nlm.nih.gov
Atherosclerosis is the underlying cause of heart attack and stroke. Early observations that
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …
HDL cholesterol efflux capacity and incident cardiovascular events
Background It is unclear whether high-density lipoprotein (HDL) cholesterol concentration
plays a causal role in atherosclerosis. A more important factor may be HDL cholesterol efflux …
plays a causal role in atherosclerosis. A more important factor may be HDL cholesterol efflux …
[HTML][HTML] Lipoproteins and lipids in cardiovascular disease: from mechanistic insights to therapeutic targeting
J Soppert, M Lehrke, N Marx, J Jankowski… - Advanced drug delivery …, 2020 - Elsevier
With cardiovascular disease being the leading cause of morbidity and mortality worldwide,
effective and cost-efficient therapies to reduce cardiovascular risk are highly needed. Lipids …
effective and cost-efficient therapies to reduce cardiovascular risk are highly needed. Lipids …
Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management
Even at low-density lipoprotein cholesterol (LDL-C) goal, patients with cardiometabolic
abnormalities remain at high risk of cardiovascular events. This paper aims (i) to critically …
abnormalities remain at high risk of cardiovascular events. This paper aims (i) to critically …
High-density lipoproteins: nature's multifunctional nanoparticles
High-density lipoproteins (HDL) are endogenous nanoparticles involved in the transport and
metabolism of cholesterol, phospholipids, and triglycerides. HDL is well-known as the …
metabolism of cholesterol, phospholipids, and triglycerides. HDL is well-known as the …
Dissecting lipid metabolism alterations in SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-
19 pandemic that has infected over a hundred million people globally. There have been …
19 pandemic that has infected over a hundred million people globally. There have been …
High-density lipoproteins during sepsis: from bench to bedside
High-density lipoproteins (HDLs) represent a family of particle characterized by the
presence of apolipoprotein AI (apoA-I) and by their ability to transport cholesterol from …
presence of apolipoprotein AI (apoA-I) and by their ability to transport cholesterol from …
HDL-targeted therapies: progress, failures and future
Since the discovery in the 1970s that plasma levels of high-density lipoprotein cholesterol
(HDL-C) are inversely associated with cardiovascular outcome, it has been postulated that …
(HDL-C) are inversely associated with cardiovascular outcome, it has been postulated that …
Cholesterol transport system: an integrated cholesterol transport model involved in atherosclerosis
XH Yu, DW Zhang, XL Zheng, CK Tang - Progress in Lipid Research, 2019 - Elsevier
Atherosclerosis, the pathological basis of most cardiovascular disease (CVD), is closely
associated with cholesterol accumulation in the arterial intima. Excessive cholesterol is …
associated with cholesterol accumulation in the arterial intima. Excessive cholesterol is …