Iodine deficiency, maternal hypothyroxinemia and endocrine disrupters affecting fetal brain development: a sco** review

R Grossklaus, KP Liesenkötter, K Doubek, H Völzke… - Nutrients, 2023 - mdpi.com
This sco** review critically discusses the publications of the last 30 years on the impact of
mild to moderate iodine deficiency and the additional impact of endocrine disrupters during …

Calcium ions aggravate Alzheimer's disease through the aberrant activation of neuronal networks, leading to synaptic and cognitive deficits

PP Guan, LL Cao, Y Yang, P Wang - Frontiers in molecular …, 2021 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disease that is characterized by the
production and deposition of β-amyloid protein (Aβ) and hyperphosphorylated tau, leading …

Distribution of 2, 2′, 5, 5′-tetrachlorobiphenyl (PCB52) metabolites in adolescent rats after acute nose-only inhalation exposure

AJ Bullert, X Li, B Gautam, H Wang… - … science & technology, 2024 - ACS Publications
Inhalation of PCB-contaminated air is increasingly recognized as a route for PCB exposure.
Because limited information about the disposition of PCBs following inhalation exposure is …

Assessment of polychlorinated biphenyls and their hydroxylated metabolites in postmortem human brain samples: age and brain region differences

X Li, MM Hefti, RF Marek, KC Hornbuckle… - … science & technology, 2022 - ACS Publications
Exposure to polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-
PCBs) has been implicated in neurodevelopmental disorders. However, the distribution of …

Structure–Activity Relationship of Lower Chlorinated Biphenyls and Their Human-Relevant Metabolites for Astrocyte Toxicity

N Paranjape, LE Dean, A Martinez… - Chemical research in …, 2023 - ACS Publications
Exposure to polychlorinated biphenyls (PCBs) is associated with developmental
neurotoxicity and neurodegenerative disorders; however, the underlying mechanisms of …

Predicted versus observed activity of PCB mixtures toward the ryanodine receptor

JA Griffin, X Li, HJ Lehmler, EB Holland - Neurotoxicology, 2024 - Elsevier
Non-dioxin-like polychlorinated biphenyls (NDL PCBs) alter the activity of the ryanodine
receptor (RyR), and this activity is linked to developmental neurotoxicity. Most work to date …

The disposition of polychlorinated biphenyls (PCBs) differs between germ-free and conventional mice

X Li, JJ Lim, K Wang, B Prasad, DK Bhatt, JY Cui… - Environmental …, 2022 - Elsevier
The disposition of toxicants, such as polychlorinated biphenyls (PCBs), in germ-free (GF) vs.
conventional (CV) mice has received little attention to date. Here, we investigate PCB levels …

Dioxins and their impact: a review of toxicity, persistence, and novel remediation strategies

N Mathew, A Somanathan, A Tirpude, AM Pillai… - Analytical …, 2025 - pubs.rsc.org
Dioxins rank among the most hazardous persistent organic pollutants, presenting a serious
threat due to their long environmental lifespan and capacity for bioaccumulation. This …

Selective dopaminergic neurotoxicity modulated by inherent cell-type specific neurobiology

F Currim, R Tanwar, JM Brown-Leung, N Paranjape… - NeuroToxicology, 2024 - Elsevier
Parkinson's disease (PD) is a debilitating neurodegenerative disease affecting millions of
individuals worldwide. Hallmark features of PD pathology are the formation of Lewy bodies …

Exploring the impact of polychlorinated biphenyls on comorbidity and potential mitigation strategies

Y Gao, H Lu, H Zhou, J Tan - Frontiers in Public Health, 2024 - frontiersin.org
Introduction Polychlorinated Biphenyls (PCBs) persist in the environment and accumulate in
humans. Currently, there is a lack of understanding about the overall impact of PCBs on …