The NMDA-R hypofunction model of schizophrenia started with the clinical observation of
the precipitation of psychotic symptoms in patients with schizophrenia exposed to PCP or …

The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

Schizophrenia is a psychiatric disorder characterised by symptoms in three domains:
positive (eg delusions, hallucinations), negative (eg social withdrawal, lack of motivation) …

Since the introduction of chlorpromazine and throughout the development of the new-
generation antipsychotic drugs (APDs) beginning with clozapine, the D 2 receptor has been …

Many risk genes interact synergistically to produce schizophrenia and many
neurotransmitter interactions have been implicated. We have developed a circuit-based …

This introductory article to the special edition on glutamate neurotransmission in
neuropsychiatric disorders provides an overview of glutamate neurotransmitter system …

Schizophrenia is a serious mental disorder that affects up to 1% of the population worldwide.
As of yet, neurochemical mechanisms underlying schizophrenia remain unknown. To date …

Importance In addition to dopaminergic hyperactivity, hypofunction of theN-methyl-d-
aspartate receptor (NMDAR) has an important role in the pathophysiology of schizophrenia …

Objective: Patients with schizophrenia frequently present with negative symptoms and
cognitive impairments for which no effective treatments are known. Agents that act at the …

Glycine transporters are endogenous regulators of the dual functions of glycine, which acts
as a classical inhibitory neurotransmitter at glycinergic synapses and as a modulator of …