Parkinson's disease prevalence is rapidly increasing in an aging global population. With this
increase comes exponentially rising social and economic costs, emphasizing the immediate …

Parkinson's Disease (PD) is a common and progressive neurodegenerative disorder
characterised by motor impairments as well as non-motor symptoms. While dopamine …

The protein α-synuclein has a central role in the pathogenesis of Parkinson's disease. Like
that of other proteins that accumulate in neurodegenerative disease, however, the function …

Cell senescence has been implicated in the pathology of Parkinson's disease (PD). Both
abnormal α-synuclein aggregation and iron deposition are suggested to be the triggers …

A plethora of studies indicate that iron metabolism is dysregulated in Parkinson's disease
(PD). The literature reveals well-documented alterations consistent with established dogma …

Iron is an essential component in many biological processes in the human body. It is critical
for the visual phototransduction cascade in the retina. However, excess iron can be toxic …

There is a continued unmet need for treatments that can slow Parkinson's disease
progression due to the lack of understanding behind the molecular mechanisms underlying …

Brain iron homeostasis is maintained through the normal function of blood–brain barrier and
iron regulation at the systemic and cellular levels, which is fundamental to normal brain …

Both iron deposition and α-synuclein aggregation are neuropathological hallmarks of
Parkinson's disease (PD). We aimed to summarize the extensive interactions between these …

Parkinson's disease (PD) is a common neurodegenerative disease with aggregation of α-
synuclein (α-syn) in substantia nigra (SN). The association between the α-syn and …