As an intelligent disease, tumors apply several pathways to evade the immune system. It can
use alternative routes to bypass intracellular signaling pathways, such as nuclear factor-κB …

Researchers have tried to find novel strategies for cancer treatment in the past decades.
Among the utilized methods, administering oncolytic viruses (OVs) alone or combined with …

Simple Summary Glioblastoma multiforme (GBM) is the most aggressive type of brain tumor
with dismal survival and poor response to conventional therapies. Therefore, the …

Hematologic malignancies comprise a considerable part of cancers with high mortality at
any age. Since the introduction of hematopoietic stem cell transplantation (HSCT), the …

During pregnancy, the fetal-maternal interface underlies several dynamic alterations to
permit the fetus to be cultivated and developed in the uterus, in spite of being identifies by …

Immunotherapy utilizing tumor-infiltrating lymphocytes (TILs) is a promising approach for
cancer treatment. Pentoxifylline (PTXF), a xanthine derivative, exhibits antitumor properties …

Recent advances in cancer immunotherapy have raised hopes for treating cancers that are
resistant to conventional therapies. Among the various immunotherapy methods, the …

Impaired lung epithelial cell regeneration following injury may contribute to the development
of pulmonary fibrosis. Epithelial-mesenchymal transition (EMT) is a critical event in …

Background Hypoxia inducible factor-1 (HIF-1) is considered as the most activated
transcriptional factor in response to low oxygen level or hypoxia. HIF-1 binds the hypoxia …

Introduction Thrombocytopenia is a common consequence of leukemia that affects the
outcome of hematopoietic stem cell transplantation (HSCT). The stromal damage of bone …