Neutrophils are innate immune phagocytes that have a central role in immune defence. Our
understanding of the role of neutrophils in pathogen clearance, immune regulation and …

Infection with Mycobacterium tuberculosis causes> 1.5 million deaths worldwide annually.
Innate immune cells are the first to encounter M. tuberculosis, and their response dictates …

Although extracellular ATP is abundant at sites of inflammation, its role in activating
inflammasome signalling in neutrophils is not well characterized. In the current study, we …

Summary 15 years ago, the fundamental biology of an inflammatory signaling complex
eventually dubbed “the inflammasome” began to unravel in chronologic parallel with the …

Macrophages infected with Gram-negative bacteria expressing Type III secretion system
(T3SS) activate the NLRC4 inflammasome, resulting in Gasdermin D (GSDMD)-dependent …

The macrophage NLRC4 inflammasome drives potent innate immune responses against
Salmonella by eliciting caspase-1-dependent proinflammatory cytokine production (eg …

Inflammasomes are cytosolic multiprotein complexes that assemble in response to a variety
of infectious and noxious insults. Inflammasomes play a critical role in the initiation of innate …

Induction, production, and release of proinflammatory cytokines are essential steps to
establish an effective host defense. Cytokines of the interleukin-1 (IL-1) family induce …

Injection of effector proteins to block host innate immune signaling is a common strategy
used by many pathogenic organisms to establish an infection. For example, pathogenic …

While the mammalian macrophage phenotypes have been intensively studied in vitro, the
dynamic of their phenotypic polarization has never been investigated in live vertebrates. We …