Modeling tubercular ESX-1 secretion using Mycobacterium marinum

AE Chirakos, A Balaram, W Conrad… - … and Molecular Biology …, 2020 - journals.asm.org
Pathogenic mycobacteria cause chronic and acute diseases ranging from human
tuberculosis (TB) to nontubercular infections. Mycobacterium tuberculosis causes both acute …

Nucleoid‐associated proteins of mycobacteria come with a distinctive flavor

M Santoshi, P Tare, V Nagaraja - Molecular Microbiology, 2024 - Wiley Online Library
In every bacterium, nucleoid‐associated proteins (NAPs) play crucial roles in chromosome
organization, replication, repair, gene expression, and other DNA transactions. Their central …

The antagonistic transcription factors, EspM and EspN, regulate the ESX-1 secretion system in M. marinum

KR Nicholson, RM Cronin, RJ Prest, AR Menon… - Mbio, 2024 - journals.asm.org
Bacterial pathogens use protein secretion systems to transport virulence factors and
regulate gene expression. Among pathogenic mycobacteria, including Mycobacterium …

NapM, a new nucleoid‐associated protein, broadly regulates gene expression and affects mycobacterial resistance to anti‐tuberculosis drugs

Y Liu, H Wang, T Cui, X Zhou, Y Jia… - Molecular …, 2016 - Wiley Online Library
Nucleoid‐associated proteins (NAPs) play important roles in the global organization of
bacterial chromosomes. However, potential NAPs and their functions are barely …

Frequently arising ESX-1-associated phase variants influence Mycobacterium tuberculosis fitness in the presence of host and antibiotic pressures

MJ Luna, PO Oluoch, J Miao, P Culviner… - mBio, 2025 - journals.asm.org
Mycobacterium tuberculosis (Mtb) exhibits an impressive ability to adapt to rapidly changing
environments, despite its genome's apparent stability. Recently, phase variation through …

Role of intragenic binding of cAMP responsive protein (CRP) in regulation of the succinate dehydrogenase genes Rv0249c-Rv0247c in TB complex mycobacteria

GS Knapp, A Lyubetskaya, MW Peterson… - Nucleic Acids …, 2015 - academic.oup.com
Bacterial pathogens adapt to changing environments within their hosts, and the signaling
molecule adenosine 3′, 5′-cyclic monophosphate (cAMP) facilitates this process. In this …

Expression and regulatory networks of Mycobacterium tuberculosis PE/PPE family antigens

W Li, W Deng, J **e - Journal of cellular physiology, 2019 - Wiley Online Library
PE/PPE family antigens are distributed mainly in pathogenic mycobacteria and serve as
potential antituberculosis (TB) vaccine components. Some PE/PPE family antigens can …

Mycobacterial nucleoid associated proteins: an added dimension in gene regulation

NL Kriel, J Gallant, N van Wyk, P van Helden… - Tuberculosis, 2018 - Elsevier
Nucleoid associated proteins (NAPs) are known organisers of chromosomal structure and
regulators of transcriptional expression. The number of proposed NAPs in mycobacteria are …

The EspN transcription factor is an infection-dependent regulator of the ESX-1 system in M. marinum

KR Nicholson, RM Cronin, AR Menon, MK Jennisch… - bioRxiv, 2023 - biorxiv.org
Bacterial pathogens use protein secretion systems to translocate virulence factors into the
host and to control bacterial gene expression. The ESX-1 (ESAT-6 system 1) secretion …

Defining the functionally important domain and amino acid residues in mycobacterium tuberculosis integration host factor for genome stability, DNA binding, and …

N Sharadamma, Y Harshavardhana… - Journal of …, 2017 - journals.asm.org
The integration host factor of Mycobacterium tuberculosis (mIHF) consists of a single
polypeptide chain, the product of the ihf gene. We previously revealed that mIHF is a novel …