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Modeling tubercular ESX-1 secretion using Mycobacterium marinum
AE Chirakos, A Balaram, W Conrad… - … and Molecular Biology …, 2020 - journals.asm.org
Pathogenic mycobacteria cause chronic and acute diseases ranging from human
tuberculosis (TB) to nontubercular infections. Mycobacterium tuberculosis causes both acute …
tuberculosis (TB) to nontubercular infections. Mycobacterium tuberculosis causes both acute …
Nucleoid‐associated proteins of mycobacteria come with a distinctive flavor
M Santoshi, P Tare, V Nagaraja - Molecular Microbiology, 2024 - Wiley Online Library
In every bacterium, nucleoid‐associated proteins (NAPs) play crucial roles in chromosome
organization, replication, repair, gene expression, and other DNA transactions. Their central …
organization, replication, repair, gene expression, and other DNA transactions. Their central …
The antagonistic transcription factors, EspM and EspN, regulate the ESX-1 secretion system in M. marinum
KR Nicholson, RM Cronin, RJ Prest, AR Menon… - Mbio, 2024 - journals.asm.org
Bacterial pathogens use protein secretion systems to transport virulence factors and
regulate gene expression. Among pathogenic mycobacteria, including Mycobacterium …
regulate gene expression. Among pathogenic mycobacteria, including Mycobacterium …
NapM, a new nucleoid‐associated protein, broadly regulates gene expression and affects mycobacterial resistance to anti‐tuberculosis drugs
Y Liu, H Wang, T Cui, X Zhou, Y Jia… - Molecular …, 2016 - Wiley Online Library
Nucleoid‐associated proteins (NAPs) play important roles in the global organization of
bacterial chromosomes. However, potential NAPs and their functions are barely …
bacterial chromosomes. However, potential NAPs and their functions are barely …
Frequently arising ESX-1-associated phase variants influence Mycobacterium tuberculosis fitness in the presence of host and antibiotic pressures
Mycobacterium tuberculosis (Mtb) exhibits an impressive ability to adapt to rapidly changing
environments, despite its genome's apparent stability. Recently, phase variation through …
environments, despite its genome's apparent stability. Recently, phase variation through …
Role of intragenic binding of cAMP responsive protein (CRP) in regulation of the succinate dehydrogenase genes Rv0249c-Rv0247c in TB complex mycobacteria
Bacterial pathogens adapt to changing environments within their hosts, and the signaling
molecule adenosine 3′, 5′-cyclic monophosphate (cAMP) facilitates this process. In this …
molecule adenosine 3′, 5′-cyclic monophosphate (cAMP) facilitates this process. In this …
Expression and regulatory networks of Mycobacterium tuberculosis PE/PPE family antigens
W Li, W Deng, J **e - Journal of cellular physiology, 2019 - Wiley Online Library
PE/PPE family antigens are distributed mainly in pathogenic mycobacteria and serve as
potential antituberculosis (TB) vaccine components. Some PE/PPE family antigens can …
potential antituberculosis (TB) vaccine components. Some PE/PPE family antigens can …
Mycobacterial nucleoid associated proteins: an added dimension in gene regulation
Nucleoid associated proteins (NAPs) are known organisers of chromosomal structure and
regulators of transcriptional expression. The number of proposed NAPs in mycobacteria are …
regulators of transcriptional expression. The number of proposed NAPs in mycobacteria are …
The EspN transcription factor is an infection-dependent regulator of the ESX-1 system in M. marinum
KR Nicholson, RM Cronin, AR Menon, MK Jennisch… - bioRxiv, 2023 - biorxiv.org
Bacterial pathogens use protein secretion systems to translocate virulence factors into the
host and to control bacterial gene expression. The ESX-1 (ESAT-6 system 1) secretion …
host and to control bacterial gene expression. The ESX-1 (ESAT-6 system 1) secretion …
Defining the functionally important domain and amino acid residues in mycobacterium tuberculosis integration host factor for genome stability, DNA binding, and …
N Sharadamma, Y Harshavardhana… - Journal of …, 2017 - journals.asm.org
The integration host factor of Mycobacterium tuberculosis (mIHF) consists of a single
polypeptide chain, the product of the ihf gene. We previously revealed that mIHF is a novel …
polypeptide chain, the product of the ihf gene. We previously revealed that mIHF is a novel …