[HTML][HTML] Neuroprotection in glaucoma: mechanisms beyond intraocular pressure lowering
Glaucoma is a common, complex, multifactorial neurodegenerative disease characterized
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …
Cholinergic nervous system and glaucoma: From basic science to clinical applications
The cholinergic system has a crucial role to play in visual function. Although cholinergic
drugs have been a focus of attention as glaucoma medications for reducing eye pressure …
drugs have been a focus of attention as glaucoma medications for reducing eye pressure …
AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma
N Belforte, J Agostinone, L Alarcon-Martinez… - Molecular …, 2021 - Springer
Background The maintenance of complex dendritic arbors and synaptic transmission are
processes that require a substantial amount of energy. Bioenergetic decline is a prominent …
processes that require a substantial amount of energy. Bioenergetic decline is a prominent …
Glaucoma as a metabolic optic neuropathy: making the case for nicotinamide treatment in glaucoma
Mitochondrial dysfunction may be an important, if not essential, component of human
glaucoma. Using transcriptomics followed by molecular and neurobiological techniques, we …
glaucoma. Using transcriptomics followed by molecular and neurobiological techniques, we …
Association between glaucoma susceptibility with combined defects in mitochondrial oxidative phosphorylation and fatty acid beta oxidation
Glaucoma is one of the leading causes of visual impairment and blindness worldwide, and
is characterized by the progressive damage of retinal ganglion cells (RGCs) and the atrophy …
is characterized by the progressive damage of retinal ganglion cells (RGCs) and the atrophy …
Neurodegeneration in Alzheimer's disease and glaucoma: overlaps and missing links
The eye is said to be the window into the brain. Alzheimer's disease (AD) and glaucoma
both being diseases of the elderly, have several epidemiological and histological overlaps …
both being diseases of the elderly, have several epidemiological and histological overlaps …
Resveratrol protects retinal ganglion cells against ischemia induced damage by increasing Opa1 expression
Y Pang, M Qin, P Hu, K Ji, R **ao… - International …, 2020 - spandidos-publications.com
Loss of idiopathic retinal ganglion cells (RGCs) leads to irreversible vision defects and is
considered the primary characteristic of glaucoma. However, effective treatment strategies in …
considered the primary characteristic of glaucoma. However, effective treatment strategies in …
Primary congenital glaucoma
F Ko, M Papadopoulos, PT Khaw - Progress in brain research, 2015 - Elsevier
Primary congenital glaucoma (PCG) is the most common nonsyndromic glaucoma in
infancy, which can lead to blindness, or a lifetime of vision when diagnosed and treated …
infancy, which can lead to blindness, or a lifetime of vision when diagnosed and treated …
[HTML][HTML] Whole-mitochondrial genome sequencing in primary open-angle glaucoma using massively parallel sequencing identifies novel and known pathogenic …
P Sundaresan, DA Simpson, C Sambare, S Duffy… - Genetics in …, 2015 - Elsevier
Purpose The aim of this study was to determine whether mutations in mitochondrial DNA
play a role in high-pressure primary open-angle glaucoma (OMIM 137760) by analyzing …
play a role in high-pressure primary open-angle glaucoma (OMIM 137760) by analyzing …
Candidate genes involved in the susceptibility of primary open angle glaucoma
S Kumar, MA Malik, S Goswami, R Sihota, J Kaur - Gene, 2016 - Elsevier
Purpose Glaucoma is a common disease often identified by high intraocular pressure,
characteristic optic neuropathy and vision loss. It is currently a leading cause of blindness …
characteristic optic neuropathy and vision loss. It is currently a leading cause of blindness …