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CAR T-Cell-Based gene therapy for cancers: new perspectives, challenges, and clinical developments
Chimeric antigen receptor (CAR)-T cell therapy is a progressive new pillar in immune cell
therapy for cancer. It has yielded remarkable clinical responses in patients with B-cell …
therapy for cancer. It has yielded remarkable clinical responses in patients with B-cell …
Lymph node metastasis in cancer progression: molecular mechanisms, clinical significance and therapeutic interventions
Lymph nodes (LNs) are important hubs for metastatic cell arrest and growth, immune
modulation, and secondary dissemination to distant sites through a series of mechanisms …
modulation, and secondary dissemination to distant sites through a series of mechanisms …
Anti-BCMA CAR T-cell therapy bb2121 in relapsed or refractory multiple myeloma
Background Preclinical studies suggest that bb2121, a chimeric antigen receptor (CAR) T-
cell therapy that targets B-cell maturation antigen (BCMA), has potential for the treatment of …
cell therapy that targets B-cell maturation antigen (BCMA), has potential for the treatment of …
Recent advances in CAR T-cell toxicity: mechanisms, manifestations and management
Chimeric antigen receptor (CAR) T-cell therapy is an effective new treatment for hematologic
malignancies. Two CAR T-cell products are now approved for clinical use by the US FDA …
malignancies. Two CAR T-cell products are now approved for clinical use by the US FDA …
B-cell maturation antigen (BCMA) in multiple myeloma: rationale for targeting and current therapeutic approaches
Despite considerable advances in the treatment of multiple myeloma (MM) in the last
decade, a substantial proportion of patients do not respond to current therapies or have a …
decade, a substantial proportion of patients do not respond to current therapies or have a …
Current updates on generations, approvals, and clinical trials of CAR T-cell therapy
T Asmamaw Dejenie, M Tiruneh G/Medhin… - Human vaccines & …, 2022 - Taylor & Francis
Chimeric antigen receptor (CAR) T-cell therapy is a novel, customized immunotherapy that
is considered a 'living'and self-replicating drug to treat cancer, sometimes resulting in a …
is considered a 'living'and self-replicating drug to treat cancer, sometimes resulting in a …
T cells genetically modified to express an anti–B-cell maturation antigen chimeric antigen receptor cause remissions of poor-prognosis relapsed multiple myeloma
JN Brudno, I Maric, SD Hartman, JJ Rose… - Journal of Clinical …, 2018 - ascopubs.org
Purpose Therapies with novel mechanisms of action are needed for multiple myeloma (MM).
T cells can be genetically modified to express chimeric antigen receptors (CARs), which are …
T cells can be genetically modified to express chimeric antigen receptors (CARs), which are …
T cell dysfunction and exhaustion in cancer
Tumor immunotherapy is a promising therapeutic strategy for patients with advanced
cancers. T cells are key mediators of antitumor function that specifically recognize and react …
cancers. T cells are key mediators of antitumor function that specifically recognize and react …
Chimeric antigen receptor T-cells: an overview of concepts, applications, limitations, and proposed solutions
Adaptive immunity, orchestrated by B-cells and T-cells, plays a crucial role in protecting the
body from pathogenic invaders and can be used as tools to enhance the body's defense …
body from pathogenic invaders and can be used as tools to enhance the body's defense …
CAR T-cell therapy: a new era in cancer immunotherapy
Background: Cancer is one of the leading causes of death worldwide. Over the years, a
number of conventional cytotoxic approaches for neoplastic diseases has been developed …
number of conventional cytotoxic approaches for neoplastic diseases has been developed …