Biological phenoty** in sepsis and acute respiratory distress syndrome
P Sinha, NJ Meyer, CS Calfee - Annual review of medicine, 2023 - annualreviews.org
Heterogeneity in sepsis and acute respiratory distress syndrome (ARDS) is increasingly
being recognized as one of the principal barriers to finding efficacious targeted therapies …
being recognized as one of the principal barriers to finding efficacious targeted therapies …
Reappraisal of ventilator-free days in critical care research
Ventilator-free days (VFDs) are a commonly reported composite outcome measure in acute
respiratory distress syndrome trials. VFDs combine survival and duration of ventilation in a …
respiratory distress syndrome trials. VFDs combine survival and duration of ventilation in a …
[HTML][HTML] Oxygen-saturation targets for critically ill adults receiving mechanical ventilation
Background Invasive mechanical ventilation in critically ill adults involves adjusting the
fraction of inspired oxygen to maintain arterial oxygen saturation. The oxygen-saturation …
fraction of inspired oxygen to maintain arterial oxygen saturation. The oxygen-saturation …
Randomized controlled trials–a matter of design
Randomized controlled trials (RCTs) are the hallmark of evidence-based medicine and form
the basis for translating research data into clinical practice. This review summarizes …
the basis for translating research data into clinical practice. This review summarizes …
Randomised clinical trials in critical care: past, present and future
Randomised clinical trials (RCTs) are the gold standard for providing unbiased evidence of
intervention effects. Here, we provide an overview of the history of RCTs and discuss the …
intervention effects. Here, we provide an overview of the history of RCTs and discuss the …
Comparative effectiveness of fludrocortisone and hydrocortisone vs hydrocortisone alone among patients with septic shock
Importance Patients with septic shock may benefit from the initiation of corticosteroids.
However, the comparative effectiveness of the 2 most studied corticosteroid regimens …
However, the comparative effectiveness of the 2 most studied corticosteroid regimens …
States worse than death among hospitalized patients with serious illnesses
EB Rubin, AE Buehler, SD Halpern - JAMA internal medicine, 2016 - jamanetwork.com
Methods| We conducted a prospective cohort study nested within a randomized trial of
different approaches to decision making among 180 patients with serious illnesses who …
different approaches to decision making among 180 patients with serious illnesses who …
Implications of heterogeneity of treatment effect for reporting and analysis of randomized trials in critical care
Randomized clinical trials (RCTs) are conducted to guide clinicians' selection of therapies
for individual patients. Currently, RCTs in critical care often report an overall mean effect and …
for individual patients. Currently, RCTs in critical care often report an overall mean effect and …
The fragility index in multicenter randomized controlled critical care trials
Objectives: Recent literature has drawn attention to the potential inadequacy of frequentist
analysis and threshold p values as tools for reporting outcomes in clinical trials. The fragility …
analysis and threshold p values as tools for reporting outcomes in clinical trials. The fragility …
Clinical trials in critical care: can a Bayesian approach enhance clinical and scientific decision making?
Recent Bayesian reanalyses of prominent trials in critical illness have generated controversy
by contradicting the initial conclusions based on conventional frequentist analyses. Many …
by contradicting the initial conclusions based on conventional frequentist analyses. Many …