Abstract Calcium (Ca2+) signalling is of paramount importance to immunity. Regulated
increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex …

Lysosomes are the main proteolytic compartments of mammalian cells comprising of a
battery of hydrolases. Lysosomes dispose and recycle extracellular or intracellular …

The mammalian genome encodes 28 distinct members of the transient receptor potential
(TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for …

Abstract The TRP (Transient Receptor Potential) superfamily of cation channels is
remarkable in that it displays greater diversity in activation mechanisms and selectivities …

Transient receptor potential (TRP) channels are cellular sensors for a wide spectrum of
physical and chemical stimuli. They are involved in the formation of sight, hearing, touch …

The transient receptor potential (TRP) superfamily consists of a large number of cation
channels that are mostly permeable to both monovalent and divalent cations. The 28 …

The 28 mammalian members of the super-family of transient receptor potential (TRP)
channels are cation channels, mostly permeable to both monovalent and divalent cations …

Abstract TRPML1 (mucolipin 1, also known as MCOLN1) is predicted to be an intracellular
late endosomal and lysosomal ion channel protein that belongs to the mucolipin subfamily …

Abstract Members of the Transient Receptor Potential-Mucolipin (TRPML) constitute a family
of evolutionarily conserved cation channels that function predominantly in endolysosomal …

Transient receptor potential (TRP) channels are a widely expressed family of 28
evolutionarily conserved cationic ion channels that operate as primary detectors of chemical …