Tau protein is involved in various cellular processes, including having a canonical role in
binding and stabilization of microtubules in neurons. Tauopathies are neurodegenerative …

Autophagy is a conserved mechanism that degrades damaged or superfluous cellular
contents and enables nutrient recycling under starvation conditions. Many …

Importance Factors associated with synapse loss beyond amyloid-β plaques and
neurofibrillary tangles may more closely correlate with the emergence of cognitive deficits in …

Neuronal loss is the central issue in Alzheimer's disease (AD), yet no treatment developed
so far can halt AD-associated neurodegeneration. Here, we developed a monoclonal …

Pathological tau aggregates cause cognitive decline in neurodegenerative tauopathies,
including Alzheimer's disease (AD). These aggregates are prevalent within intracellular …

Alzheimer's disease begins with mild memory loss and slowly destroys memory and
thinking. Cognitive impairment in Alzheimer's disease has been associated with the …

Tau hyperphosphorylation and aggregation is a common feature of many dementia-causing
neurodegenerative diseases. Tau can be phosphorylated at up to 85 different sites, and …

Once considered unconventional cellular structures, membraneless organelles (MLOs),
cellular substructures involved in biological processes or pathways under physiological …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that comprises
amyloid-beta protein (Aβ) as a main component of neuritic plaques. Its deposition is …

The administration of promising medications for the treatment of neurodegenerative
disorders (NDDs), such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's …