Therapeutically harnessing extracellular vesicles

L Cheng, AF Hill - Nature Reviews Drug Discovery, 2022 - nature.com
The field of extracellular vesicle (EV) research has developed rapidly over the last decade
from the study of fundamental biology to a subject of significant clinical relevance. The …

Extracellular vesicle analysis

A Hendrix, L Lippens, C Pinheiro, C Théry… - Nature Reviews …, 2023 - nature.com
Cells release small, phospholipid membrane-enclosed particles, collectively referred to as
extracellular vesicles (EVs), into their surroundings to enable intercellular communication …

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

JA Welsh, DCI Goberdhan, L O'Driscoll… - Journal of …, 2024 - Wiley Online Library
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of
origin and change the functions and phenotypes of other cells. These features indicate …

Exosome processing and characterization approaches for research and technology development

JJ Lai, ZL Chau, SY Chen, JJ Hill… - Advanced …, 2022 - Wiley Online Library
Exosomes are extracellular vesicles that share components of their parent cells and are
attractive in biotechnology and biomedical research as potential disease biomarkers as well …

Formation of a protein corona on the surface of extracellular vesicles in blood plasma

EÁ Tóth, L Turiák, T Visnovitz, C Cserép… - Journal of …, 2021 - Wiley Online Library
In this study we tested whether a protein corona is formed around extracellular vesicles
(EVs) in blood plasma. We isolated medium‐sized nascent EVs of THP1 cells as well as of …

Isolation and characterization of extracellular vesicle subpopulations from tissues

R Crescitelli, C Lässer, J Lötvall - Nature protocols, 2021 - nature.com
Extracellular vesicles (EVs) are lipid bilayered membrane structures released by all cells.
Most EV studies have been performed by using cell lines or body fluids, but the number of …

[HTML][HTML] Reassessment of exosome composition

DK Jeppesen, AM Fenix, JL Franklin, JN Higginbotham… - Cell, 2019 - cell.com
The heterogeneity of small extracellular vesicles and presence of non-vesicular extracellular
matter have led to debate about contents and functional properties of exosomes. Here, we …

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the …

C Théry, KW Witwer, E Aikawa… - Journal of …, 2018 - Wiley Online Library
The last decade has seen a sharp increase in the number of scientific publications
describing physiological and pathological functions of extracellular vesicles (EVs), a …

Exosomal miR-4443 promotes cisplatin resistance in non-small cell lung carcinoma by regulating FSP1 m6A modification-mediated ferroptosis

Z Song, G Jia, P Ma, S Cang - Life sciences, 2021 - Elsevier
Aims Exosomal transfer of miRNAs affects recipient cell proliferation and chemoresistance.
Here, we aimed to investigate the role of exosomal miRNAs in controlling cisplatin …

Extracellular vesicles and neurodegenerative diseases

AF Hill - Journal of Neuroscience, 2019 - Soc Neuroscience
Extracellular vesicles (EVs) include exosomes and microvesicles and have been shown to
have roles in the CNS ranging from the removal of unwanted biomolecules to intercellular …