Taurine supplementation as a neuroprotective strategy upon brain dysfunction in metabolic syndrome and diabetes
Obesity, type 2 diabetes, and their associated comorbidities impact brain metabolism and
function and constitute risk factors for cognitive impairment. Alterations to taurine …
function and constitute risk factors for cognitive impairment. Alterations to taurine …
The neurochemical profile quantified by in vivo 1H NMR spectroscopy
Proton NMR spectroscopy is emerging from translational and preclinical neuroscience
research as an important tool for evidence based diagnosis and therapy monitoring. It …
research as an important tool for evidence based diagnosis and therapy monitoring. It …
Anaesthesia and physiological monitoring during in vivo imaging of laboratory rodents: considerations on experimental outcomes and animal welfare
JL Tremoleda, A Kerton, W Gsell - EJNMMI research, 2012 - Springer
The implementation of imaging technologies has dramatically increased the efficiency of
preclinical studies, enabling a powerful, non-invasive and clinically translatable way for …
preclinical studies, enabling a powerful, non-invasive and clinically translatable way for …
In situ microwave fixation provides an instantaneous snapshot of the brain metabolome
Brain glucose metabolism is highly heterogeneous among brain regions and continues
postmortem. In particular, we demonstrate exhaustion of glycogen and glucose and an …
postmortem. In particular, we demonstrate exhaustion of glycogen and glucose and an …
The metabolomic profile during isoflurane anesthesia differs from propofol anesthesia in the live rodent brain
R Makaryus, H Lee, M Yu, S Zhang… - Journal of Cerebral …, 2011 - journals.sagepub.com
Development of noninvasive techniques to discover new biomarkers in the live brain is
important to further understand the underlying metabolic pathways of significance for …
important to further understand the underlying metabolic pathways of significance for …
Brain mitochondrial metabolic dysfunction and glutamate level reduction in the pilocarpine model of temporal lobe epilepsy in mice
Although certain metabolic characteristics such as interictal glucose hypometabolism are
well established for temporal lobe epilepsy (TLE), its pathogenesis still remains unclear …
well established for temporal lobe epilepsy (TLE), its pathogenesis still remains unclear …
Glutamate metabolism is impaired in transgenic mice with tau hyperphosphorylation
In neurodegenerative diseases including Alzheimer's disease and frontotemporal dementia,
the protein tau is hyperphosphorylated and eventually aggregates to develop neurofibrillary …
the protein tau is hyperphosphorylated and eventually aggregates to develop neurofibrillary …
Metabolic Flux and Compartmentation Analysis in the Brain In vivo
Through significant developments and progresses in the last two decades, in vivo localized
nuclear magnetic resonance spectroscopy (MRS) became a method of choice to probe brain …
nuclear magnetic resonance spectroscopy (MRS) became a method of choice to probe brain …
Neurochemical profile of the develo** mouse cortex determined by in vivo1H NMR spectroscopy at 14.1 T and the effect of recurrent anaesthesia
J. Neurochem.(2010) 115, 1466–1477. Abstract The neurochemical profile of the cortex
develops in a region and time specific manner, which can be distorted by psychiatric and …
develops in a region and time specific manner, which can be distorted by psychiatric and …
Magnetic resonance spectroscopy in the rodent brain: experts' consensus recommendations
In vivo MRS is a non‐invasive measurement technique used not only in humans, but also in
animal models using high‐field magnets. MRS enables the measurement of metabolite …
animal models using high‐field magnets. MRS enables the measurement of metabolite …