Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells
The heat and capsaicin receptor, TRPV1, is required for the detection of painful heat by
primary afferent pain fibers (nociceptors), but the extent to which functional TRPV1 channels …
primary afferent pain fibers (nociceptors), but the extent to which functional TRPV1 channels …
TRPV1 receptors in the central nervous system: potential for previously unforeseen therapeutic applications
Increasing evidence exists to support the presence of functional transient receptor potential
vanilloid type 1 (TRPV1) channels in the brain, where these receptors are unlikely to be …
vanilloid type 1 (TRPV1) channels in the brain, where these receptors are unlikely to be …
TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus
The transient receptor potential TRPV1 is a nonselective cation channel that mediates pain
sensations and is commonly activated by a wide variety of exogenous and endogenous …
sensations and is commonly activated by a wide variety of exogenous and endogenous …
TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro
Amyloid-β peptide (Aβ) forms plaques in Alzheimer's disease (AD) and is responsible for
early cognitive deficits in AD patients. Advancing cognitive decline is accompanied by …
early cognitive deficits in AD patients. Advancing cognitive decline is accompanied by …
Tonic endovanilloid facilitation of glutamate release in brainstem descending antinociceptive pathways
Activation of transient receptor potential vanilloid-1 (TRPV1) channels in the periaqueductal
gray (PAG) activates OFF antinociceptive neurons of the rostral ventromedial medulla …
gray (PAG) activates OFF antinociceptive neurons of the rostral ventromedial medulla …
Effects of TRPV1 activation on synaptic excitation in the dentate gyrus of a mouse model of temporal lobe epilepsy
Temporal lobe epilepsy (TLE) is a condition characterized by an imbalance between
excitation and inhibition in the temporal lobe. Hallmarks of this change are axon sprouting …
excitation and inhibition in the temporal lobe. Hallmarks of this change are axon sprouting …
Endocannabinoid-mediated synaptic plasticity and addiction-related behavior
N Sidhpura, LH Parsons - Neuropharmacology, 2011 - Elsevier
Endogenous cannabinoids (eCBs) are retrograde messengers that provide feedback
inhibition of both excitatory and inhibitory transmission in brain through the activation of …
inhibition of both excitatory and inhibitory transmission in brain through the activation of …
“Hotheaded”: the role OF TRPV1 in brain functions
Abstract The TRPV1 (vanilloid 1) channel is best known for its role in sensory transmission
in the nociceptive neurons of the peripheral nervous system. Although first studied in the …
in the nociceptive neurons of the peripheral nervous system. Although first studied in the …
Immunohistochemical localization of anabolic and catabolic enzymes for anandamide and other putative endovanilloids in the hippocampus and cerebellar cortex of …
An increasing body of evidence indicates that: 1) the endocannabinoid anandamide (AEA)
and other unsaturated N-acylethanolamines (NAEs), 2) 12-(S)-lipoxygenase (12-LOX) …
and other unsaturated N-acylethanolamines (NAEs), 2) 12-(S)-lipoxygenase (12-LOX) …
Activation of transient receptor potential vanilloid 1 ameliorates tau accumulation‐induced synaptic damage and cognitive dysfunction via autophagy enhancement
T Zhang, Y Tian, X Zheng, R Li, L Hu… - CNS Neuroscience …, 2024 - Wiley Online Library
Aims The autophagy‐lysosomal pathway is important for maintaining cellular proteostasis,
while dysfunction of this pathway has been suggested to drive the aberrant intraneuronal …
while dysfunction of this pathway has been suggested to drive the aberrant intraneuronal …