In arbitrary dimension, in the discrete setting of finite-differences we prove a Carleman
estimate for a semi-discrete parabolic operator, in which the large parameter is connected to …

Heme (iron-protoporphyrin IX) is an essential co-factor involved in multiple biological
processes: oxygen transport and storage, electron transfer, drug and steroid metabolism …

Effective treatment of metastatic cancers usually requires the use of toxic chemotherapy. In
most cases, multiple drugs are used, as resistance to single agents occurs almost …

Active drug efflux transporters of the ATP binding cassette (ABC)-containing family of
proteins have a major impact on the pharmacological behavior of most of the drugs in use …

Molecular medicine has led to rapid advances in the characterization of hepatobiliary
transport systems that determine the uptake and excretion of bile salts and other biliary …

Abstract The amphetamine derivative (±)-3, 4-methylenedioxymethamphetamine (MDMA,
ecstasy) is a popular recreational drug among young people, particularly those involved in …

▪ Abstract Liver X receptors (LXRs) and farnesoid X receptor (FXR) are nuclear receptors
that function as intracellular sensors for sterols and bile acids, respectively. In response to …

When looking for a book on fish toxicology, you might find one that discusses the
biochemical and molecular aspects, or one that focuses aquatic toxicology in general. You …

▪ Abstract Bile salts are the major organic solutes in bile and undergo extensive
enterohepatic circulation. Hepatocellular bile salt uptake is mediated predominantly by the …

Glucuronidation is a well-recognized phase II metabolic pathway for a variety of chemicals
including drugs and endogenous substances. Although it is usually the secondary metabolic …