Abstract c-kit is a classical proto-oncogene that encodes a receptor tyrosine kinase (RTK)
that responds to stem cell factor (SCF). C-KIT signaling is a critical regulator of cell …

Background The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by
severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a global public health …

Signal Transducer and Activator of Transcription (STAT) 3 and 5 are important effectors of
cellular transformation, and aberrant STAT3 and STAT5 signaling have been demonstrated …

Systemic mastocytosis (SM) is a heterogeneous disease, vast majority of these patients
have a gain of function mutation in the gene encoding the tyrosine kinase KIT (KITD816V). A …

The limited efficacy of chimeric antigen receptor (CAR) T cell therapy for solid tumors
necessitates engineering strategies that promote functional persistence in an …

Abstract c-Kit is a type III receptor tyrosine kinase (RTK) that has an essential role in various
biological functions including gametogenesis, melanogenesis, hematopoiesis, cell survival …

In systemic mastocytosis (SM), clinical problems arise from factor-independent proliferation
of mast cells (MCs) and the increased release of mediators by MCs, but no human cell line …

Although more than 90% systemic mastocytosis (SM) patients express gain of function
mutations in the KIT receptor, recent next generation sequencing has revealed the presence …

Abstract Regulatory FOXP3+ T cells (Tregs) constitute 5% to 10% of T cells in the normal
human skin. They play an important role in the induction and maintenance of immunological …

Mutated oncogenic KIT is a therapeutic target in melanoma. We conducted a multicenter
phase II trial on the KIT inhibitor nilotinib in patients with unresectable melanoma harboring …