Chronic active lesions (CAL) are an important manifestation of chronic inflammation in
multiple sclerosis and have implications for non-relapsing biological progression. In recent …

MRI has improved the diagnostic work-up of multiple sclerosis, but inappropriate image
interpretation and application of MRI diagnostic criteria contribute to misdiagnosis. Some …

Importance In multiple sclerosis (MS), chronic active lesions, which previously could only be
detected at autopsy, can now be identified on susceptibility-based magnetic resonance …

In the majority of patients multiple sclerosis starts with a relapsing remitting course (RRMS),
which may at later times transform into secondary progressive disease (SPMS). In a minority …

During the past decades, better understanding of relapsing-remitting multiple sclerosis
disease mechanisms have led to the development of several disease-modifying therapies …

Recent data suggest that multiple sclerosis white matter lesions surrounded by a rim of iron
containing microglia, termed iron rim lesions, signify patients with more severe disease …

A better understanding of the pathological mechanisms that drive neurodegeneration in
individuals with multiple sclerosis is needed to develop therapies that will effectively treat …

In multiple sclerosis (MS), iron accumulates inside activated microglia/macrophages at
edges of some chronic demyelinated lesions, forming rims. In susceptibility-based magnetic …

BACKGROUND. In some active multiple sclerosis (MS) lesions, a strong immune reaction at
the lesion edge may contain growth and thereby isolate the lesion from the surrounding …

Objective Iron may contribute to the pathogenesis and progression of multiple sclerosis (MS)
due to its accumulation in the human brain with age. Our study focused on nonheme iron …