CCN proteins in the musculoskeletal system: current understanding and challenges in physiology and pathology

V Giusti, K Scotlandi - Journal of Cell Communication and …, 2021 - Wiley Online Library
The acronym for the CCN family was recently revised to represent “cellular communication
network”. These six, small, cysteine‐enriched and evolutionarily conserved proteins are …

Cellular communication network factor 3 in cartilage development and maintenance

S Kubota, H Kawaki, B Perbal, K Kawata… - Journal of Cell …, 2021 - Springer
Cellular communication network factor (CCN) 3 is one of the classical members of the CCN
family, which are characterized by common molecular structures and multiple functionalities …

CCN3/NOV gene expression in human prostate cancer is directly suppressed by the androgen receptor

L Wu, C Runkle, HJ **, J Yu, J Li, X Yang, T Kuzel… - Oncogene, 2014 - nature.com
Androgen receptor (AR) has essential roles during prostate cancer progression. With
genome-wide AR-binding sites mapped to high resolution, studies have recently reported …

Structural analyses of von Willebrand factor C domains of collagen 2A and CCN3 reveal an alternative mode of binding to bone morphogenetic protein-2

ER Xu, EE Blythe, G Fischer, M Hyvönen - Journal of Biological Chemistry, 2017 - ASBMB
Bone morphogenetic proteins (BMPs) are secreted growth factors that promote
differentiation processes in embryogenesis and tissue development. Regulation of BMP …

Novel role of miR‐181a in cartilage metabolism

K Sumiyoshi, S Kubota, T Ohgawara… - Journal of cellular …, 2013 - Wiley Online Library
Micro RNA (miRNA) is a small non‐coding post‐transcriptional RNA regulator that is
involved in a variety of biological events. In order to specify the role of miRNAs in cartilage …

CCN3 modulates bone turnover and is a novel regulator of skeletal metastasis

V Ouellet, PM Siegel - Journal of cell communication and signaling, 2012 - Springer
The CCN family of proteins is composed of six secreted proteins (CCN1-6), which are
grouped together based on their structural similarity. These matricellular proteins are …

Tumor-derived thymic stromal lymphopoietin enhances lung metastasis through an alveolar macrophage-dependent mechanism

L Burkard-Mandel, R O'Neill, S Colligan… - …, 2018 - Taylor & Francis
It is well-recognized that macrophages, which arise from circulating precursors, enhance
tumor progression in patients and animal models. However, less is known regarding the role …

Regulation of cellular communication network factor 2 (CCN2) in breast cancer cells via the cell-type dependent interplay between CCN2 and glycolysis

S Akashi, T Nishida, T Mizukawa, K Kawata… - journal of oral …, 2020 - Elsevier
Objectives Anti-osteoclastic treatments for breast cancer occasionally cause medication-
related osteonecrosis of the jaw. Moreover, elevated glycolytic activity, which is known as …

High NOV/CCN3 expression during high-fat diet pregnancy in mice affects GLUT3 expression and the mTOR pathway

H Wang, B Huang, A Hou, L Xue… - American Journal …, 2021 - journals.physiology.org
We investigated the expression levels of nephroblastoma overexpressed [NOV or CCN3
(cellular communication network factor 3)] in the serum and placenta of pregnant women …

Extracellular matrix in obesity–cancer interactions

SC Barreto, CA Hopkins, M Bhowmick… - … molecular biology and …, 2015 - degruyter.com
Obesity or overweight is a risk factor for several health disorders such as type 2 diabetes,
hypertension, and certain cancers. Furthermore, obesity affects almost all body systems …