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CCN proteins in the musculoskeletal system: current understanding and challenges in physiology and pathology
The acronym for the CCN family was recently revised to represent “cellular communication
network”. These six, small, cysteine‐enriched and evolutionarily conserved proteins are …
network”. These six, small, cysteine‐enriched and evolutionarily conserved proteins are …
Cellular communication network factor 3 in cartilage development and maintenance
S Kubota, H Kawaki, B Perbal, K Kawata… - Journal of Cell …, 2021 - Springer
Cellular communication network factor (CCN) 3 is one of the classical members of the CCN
family, which are characterized by common molecular structures and multiple functionalities …
family, which are characterized by common molecular structures and multiple functionalities …
CCN3/NOV gene expression in human prostate cancer is directly suppressed by the androgen receptor
Androgen receptor (AR) has essential roles during prostate cancer progression. With
genome-wide AR-binding sites mapped to high resolution, studies have recently reported …
genome-wide AR-binding sites mapped to high resolution, studies have recently reported …
Structural analyses of von Willebrand factor C domains of collagen 2A and CCN3 reveal an alternative mode of binding to bone morphogenetic protein-2
Bone morphogenetic proteins (BMPs) are secreted growth factors that promote
differentiation processes in embryogenesis and tissue development. Regulation of BMP …
differentiation processes in embryogenesis and tissue development. Regulation of BMP …
Novel role of miR‐181a in cartilage metabolism
K Sumiyoshi, S Kubota, T Ohgawara… - Journal of cellular …, 2013 - Wiley Online Library
Micro RNA (miRNA) is a small non‐coding post‐transcriptional RNA regulator that is
involved in a variety of biological events. In order to specify the role of miRNAs in cartilage …
involved in a variety of biological events. In order to specify the role of miRNAs in cartilage …
CCN3 modulates bone turnover and is a novel regulator of skeletal metastasis
The CCN family of proteins is composed of six secreted proteins (CCN1-6), which are
grouped together based on their structural similarity. These matricellular proteins are …
grouped together based on their structural similarity. These matricellular proteins are …
Tumor-derived thymic stromal lymphopoietin enhances lung metastasis through an alveolar macrophage-dependent mechanism
L Burkard-Mandel, R O'Neill, S Colligan… - …, 2018 - Taylor & Francis
It is well-recognized that macrophages, which arise from circulating precursors, enhance
tumor progression in patients and animal models. However, less is known regarding the role …
tumor progression in patients and animal models. However, less is known regarding the role …
Regulation of cellular communication network factor 2 (CCN2) in breast cancer cells via the cell-type dependent interplay between CCN2 and glycolysis
S Akashi, T Nishida, T Mizukawa, K Kawata… - journal of oral …, 2020 - Elsevier
Objectives Anti-osteoclastic treatments for breast cancer occasionally cause medication-
related osteonecrosis of the jaw. Moreover, elevated glycolytic activity, which is known as …
related osteonecrosis of the jaw. Moreover, elevated glycolytic activity, which is known as …
High NOV/CCN3 expression during high-fat diet pregnancy in mice affects GLUT3 expression and the mTOR pathway
H Wang, B Huang, A Hou, L Xue… - American Journal …, 2021 - journals.physiology.org
We investigated the expression levels of nephroblastoma overexpressed [NOV or CCN3
(cellular communication network factor 3)] in the serum and placenta of pregnant women …
(cellular communication network factor 3)] in the serum and placenta of pregnant women …
Extracellular matrix in obesity–cancer interactions
SC Barreto, CA Hopkins, M Bhowmick… - … molecular biology and …, 2015 - degruyter.com
Obesity or overweight is a risk factor for several health disorders such as type 2 diabetes,
hypertension, and certain cancers. Furthermore, obesity affects almost all body systems …
hypertension, and certain cancers. Furthermore, obesity affects almost all body systems …