Neonatal sepsis

AL Shane, PJ Sánchez, BJ Stoll - The lancet, 2017 - thelancet.com
Neonatal sepsis is the cause of substantial morbidity and mortality. Precise estimates of
neonatal sepsis burden vary by setting. Differing estimates of disease burden have been …

Infant group B streptococcal disease incidence and serotypes worldwide: systematic review and meta-analyses

L Madrid, AC Seale, M Kohli-Lynch… - Clinical infectious …, 2017 - academic.oup.com
Abstract Background Group B Streptococcus (GBS) remains a leading cause of neonatal
sepsis in high-income contexts, despite declines due to intrapartum antibiotic prophylaxis …

Early-onset neonatal sepsis 2015 to 2017, the rise of Escherichia coli, and the need for novel prevention strategies

BJ Stoll, KM Puopolo, NI Hansen, PJ Sánchez… - JAMA …, 2020 - jamanetwork.com
Importance Early-onset sepsis (EOS) remains a potentially fatal newborn condition. Ongoing
surveillance is critical to optimize prevention and treatment strategies. Objective To describe …

Management of neonates born at≥ 35 0/7 weeks' gestation with suspected or proven early-onset bacterial sepsis

KM Puopolo, WE Benitz, TE Zaoutis, J Cummings… - …, 2018 - publications.aap.org
The incidence of neonatal early-onset sepsis (EOS) has declined substantially over the last
2 decades, primarily because of the implementation of evidence-based intrapartum …

A quantitative, risk-based approach to the management of neonatal early-onset sepsis

MW Kuzniewicz, KM Puopolo, A Fischer… - JAMA …, 2017 - jamanetwork.com
Importance Current algorithms for management of neonatal early-onset sepsis (EOS) result
in medical intervention for large numbers of uninfected infants. We developed multivariable …

Chorioamnionitis and neonatal outcomes

VG Jain, KA Willis, A Jobe, N Ambalavanan - Pediatric research, 2022 - nature.com
Chorioamnionitis or intrauterine inflammation is a frequent cause of preterm birth.
Chorioamnionitis can affect almost every organ of the develo** fetus. Multiple microbes …

Management of neonates born at≤ 34 6/7 weeks' gestation with suspected or proven early-onset bacterial sepsis

KM Puopolo, WE Benitz, TE Zaoutis, J Cummings… - …, 2018 - publications.aap.org
Early-onset sepsis (EOS) remains a serious and often fatal illness among infants born
preterm, particularly among newborn infants of the lowest gestational age. Currently, most …

Duration of initial empirical antibiotic therapy and outcomes in very low birth weight infants

JY Ting, A Roberts, R Sherlock, C Ojah, Z Cieslak… - …, 2019 - publications.aap.org
BACKGROUND: Overuse of antibiotics can facilitate antibiotic resistance and is associated
with adverse neonatal outcomes. We studied the association between duration of antibiotic …

Association of use of the neonatal early-onset sepsis calculator with reduction in antibiotic therapy and safety: a systematic review and meta-analysis

NB Achten, C Klingenberg, WE Benitz… - JAMA …, 2019 - jamanetwork.com
Importance The neonatal early-onset sepsis (EOS) calculator is a clinical risk stratification
tool increasingly used to guide the use of empirical antibiotics for newborns. Evidence on …

Neonatal Sepsis: The Impact of Carbapenem-Resistant and Hypervirulent Klebsiella pneumoniae

S Mukherjee, S Mitra, S Dutta, S Basu - Frontiers in Medicine, 2021 - frontiersin.org
The convergence of a vulnerable population and a notorious pathogen is devastating, as
seen in the case of sepsis occurring during the first 28 days of life (neonatal period). Sepsis …