Signaling pathways and therapeutic interventions in gastric cancer

ZN Lei, QX Teng, Q Tian, W Chen, Y **e… - Signal transduction and …, 2022 - nature.com
Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death.
Despite tremendous progress in diagnosis and therapeutic strategies and significant …

Extended lymphadenectomy for gastric cancer in the neoadjuvant era: current status, clinical implications and contentious issues

L Marano, L Carbone, GE Poto, V Restaino… - Current …, 2023 - mdpi.com
Despite its decreasing incidence, gastric cancer remains an important global healthcare
problem due to its overall high prevalence and high mortality rate. Since the MAGIC and …

Exosomal transfer of miR-501 confers doxorubicin resistance and tumorigenesis via targeting of BLID in gastric cancer

X Liu, Y Lu, Y Xu, S Hou, J Huang, B Wang, J Zhao… - Cancer letters, 2019 - Elsevier
Exosomal transfer of oncogenic miRNAs can enhance recipient cell growth, metastasis and
chemoresistance. Currently we found that microRNA-501-5p (miR-501) was overexpressed …

[HTML][HTML] Perioperative treatment in resectable gastric cancer: current perspectives and future directions

A Petrillo, L Pompella, G Tirino, A Pappalardo… - Cancers, 2019 - mdpi.com
Gastric cancer (GC) is the fifth-most common cancer worldwide and an important cause of
cancer-related-death. The growing knowledge of its molecular pathogenesis has shown that …

Claudin-6 is a single prognostic marker and functions as a tumor-promoting gene in a subgroup of intestinal type gastric cancer

T Kohmoto, K Masuda, K Shoda, R Takahashi, S Ujiro… - Gastric Cancer, 2020 - Springer
Background We aimed to identify novel tumor-promoting drivers highly expressed in gastric
cancer (GC) that contribute to worsened prognosis in affected patients. Methods Genes …

Immunological aspects of the tumor microenvironment and epithelial-mesenchymal transition in gastric carcinogenesis

J Baj, K Brzozowska, A Forma, A Maani… - International journal of …, 2020 - mdpi.com
Infection with Helicobacter pylori, a Gram-negative, microaerophilic pathogen often results in
gastric cancer in a subset of affected individuals. This explains why H. pylori is the only …

Histological and mutational profile of diffuse gastric cancer: current knowledge and future challenges

J Garcia‐Pelaez, R Barbosa‐Matos, I Gullo… - Molecular …, 2021 - Wiley Online Library
Gastric cancer (GC) pathogenesis is complex and heterogeneous, reflecting morphological,
molecular and genetic diversity. Diffuse gastric cancer (DGC) and intestinal gastric cancer …

Exosomal transfer of macrophage-derived miR-223 confers doxorubicin resistance in gastric cancer

H Gao, J Ma, Y Cheng, P Zheng - OncoTargets and therapy, 2020 - Taylor & Francis
Purpose Macrophages are a major component of the tumour microenvironment and play an
important role in chemoresistance of cancer. However, how exosomal microRNAs (miRNAs) …

Multimodality treatment for localized gastric cancer: state of the art and new insights

A Petrillo, EC Smyth - Current Opinion in Oncology, 2020 - journals.lww.com
Multimodality treatment represents the standard of care for resectable gastric cancer.
Perioperative chemotherapy with FLOT is the standard treatment in western countries; in …

Curcumin micelles suppress gastric tumor cell growth by upregulating ROS generation, disrupting redox equilibrium and affecting mitochondrial bioenergetics

X Lin, L Wang, L Zhao, Z Zhu, TZ Chen, S Chen… - Food & function, 2020 - pubs.rsc.org
Gastric cancer is the fourth most common cancer and the second most frequent cause of
cancer death worldwide. Chemotherapy is an important treatment. However, traditional …