Trimethylamine N-oxide (TMAO) is a biologically active molecule and is a putative promoter
of chronic diseases including atherosclerosis in humans. Host intestinal bacteria produce its …

Proteins are marginally stable, and the folding/unfolding equilibrium of proteins in aqueous
solution can easily be altered by the addition of small organic molecules known as …

Trimethylamine N-oxide (TMAO) is a small organic compound whose concentration in blood
increases after ingesting dietary l-carnitine and phosphatidylcholine. Recent clinical studies …

We report experimental and computational studies investigating the effects of three
osmolytes, trimethylamine N-oxide (TMAO), betaine, and glycine, on the hydrophobic …

Although it is widely known that trimethylamine N-oxide (TMAO), an osmolyte used by
nature, stabilizes the folded state of proteins, the underlying mechanism of action is not …

The effects of crowding in biological environments on biomolecular structure, dynamics, and
function remain not well understood. Computer simulations of atomistic models of …

Intrinsically disordered proteins (IDPs) are a unique class of proteins that have no stable
native structure, a feature that allows them to adopt a wide variety of extended and compact …

Infrared spectroscopy has played an instrumental role in the study of a wide variety of
biological questions. However, in many cases, it is impossible or difficult to rely on the …

Trimethylamine N-oxide (TMAO) is a naturally occurring protecting osmolyte that stabilizes
the folded state of proteins and also counteracts the destabilizing effect of urea on protein …

Osmolytes are small organic molecules that can modulate the stability and function of
cellular proteins by altering the chemical environment of the cell. Some of these osmolytes …