Recent progresses in the cyclization and oxidation of polyketide biosynthesis
B Zhang, HM Ge - Current Opinion in Chemical Biology, 2024 - Elsevier
Polyketides represent an important class of natural products, renowned for their intricate
structures and diverse biological activities. In contrast to common fatty acids, polyketides …
structures and diverse biological activities. In contrast to common fatty acids, polyketides …
Unraveling proton-coupled electron transfer in cofactor-free oxidase-and oxygenase-catalyzed oxygen activation: a theoretical view
QQ Wang, Y Qiao, D Wei - Physical Chemistry Chemical Physics, 2025 - pubs.rsc.org
Oxygen plays a crucial role in the metabolic processes of non-anaerobic organisms.
However, a detailed understanding of how triplet oxygen participates in the enzymatic …
However, a detailed understanding of how triplet oxygen participates in the enzymatic …
Unravelling key enzymatic steps in C-ring cleavage during angucycline biosynthesis
Angucyclines are type II polyketide natural products, often characterized by unusual
structural rearrangements through B-or C-ring cleavage of their tetracyclic backbone. While …
structural rearrangements through B-or C-ring cleavage of their tetracyclic backbone. While …
Flavin‐N5OOH Functions as both a Powerful Nucleophile and a Base in the Superfamily of Flavoenzymes
Flavoenzymes can mediate a large variety of oxidation reactions through the activation of
oxygen. However, the O2 activation chemistry of flavin enzymes is not yet fully exploited …
oxygen. However, the O2 activation chemistry of flavin enzymes is not yet fully exploited …
Antiplasmodial potential of isolated xanthones from Mesua ferrea Linn. roots: an in vitro and in silico molecular docking and pharmacokinetics study
Background Malaria is a major global health concern, particularly in tropical and subtropical
countries. With growing resistance to first-line treatment with artemisinin, there is an urgent …
countries. With growing resistance to first-line treatment with artemisinin, there is an urgent …
Mechanistic Investigation on C–C Bond Cleavage of Anthraquinone Catalyzed by an Atypical Nonheme Iron-Dependent Dioxygenase BTG13
An atypical nonheme iron-dependent dioxygenase BTG13 with a rare iron coordination of
four histidine residues and a carboxylated-lysine (Kcx) was recently reported to catalyze the …
four histidine residues and a carboxylated-lysine (Kcx) was recently reported to catalyze the …
Characterization of a novel monooxygenase originating from a deep-sea sediment metagenomic library
J Du, Y Li, Y Huang, D Zhang, L Li - Applied Microbiology and …, 2023 - Springer
Oxygenases are important biocatalysts to produce many industrially important biomolecules.
Here, a novel oxygenase, named MoxA, was identified through screening of a deep-sea …
Here, a novel oxygenase, named MoxA, was identified through screening of a deep-sea …
A flavin-monooxygenase catalyzing oxepinone formation and the complete biosynthesis of vibralactone
KN Feng, Y Zhang, M Zhang, YL Yang, JK Liu… - Nature …, 2023 - nature.com
Oxepinone rings represent one of structurally unusual motifs of natural products and the
biosynthesis of oxepinones is not fully understood. 1, 5-Seco-vibralactone (3) features an …
biosynthesis of oxepinones is not fully understood. 1, 5-Seco-vibralactone (3) features an …
Computational Study on Flavin-Catalyzed Aerobic Dioxygenation of Alkenyl Thioesters: Decomposition of Anionic Peroxides
YY Jiang, Y Li, C Chen, YX **n - The Journal of Organic …, 2024 - ACS Publications
Flavin-dependent catalysts are widely applied to aerobic monooxygenation/oxidation
reactions. In contrast, flavin-catalyzed aerobic dioxygenation reactions exhibit higher atomic …
reactions. In contrast, flavin-catalyzed aerobic dioxygenation reactions exhibit higher atomic …
Discovery of Kebanmycins with Antibacterial and Cytotoxic Activities from the Mangrove-Derived Streptomyces sp. SCSIO 40068
M Zhao, W Zhang, C Yang, L Zhang… - Journal of Natural …, 2024 - ACS Publications
Mangrove derived actinomycetes are a rich reservoir of bioactive natural products and play
important roles in pharmaceutical chemistry. In a screen of actinomycetes from mangrove …
important roles in pharmaceutical chemistry. In a screen of actinomycetes from mangrove …