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Exercise metabolism and adaptation in skeletal muscle
Viewing metabolism through the lens of exercise biology has proven an accessible and
practical strategy to gain new insights into local and systemic metabolic regulation. Recent …
practical strategy to gain new insights into local and systemic metabolic regulation. Recent …
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases
L Qian, Y Zhu, C Deng, Z Liang, J Chen… - Signal transduction and …, 2024 - nature.com
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s),
consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related …
consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related …
Flip** the metabolic switch: understanding and applying the health benefits of fasting
Objective Intermittent fasting (IF) is a term used to describe a variety of eating patterns in
which no or few calories are consumed for time periods that can range from 12 hours to …
which no or few calories are consumed for time periods that can range from 12 hours to …
PGC1α in the kidney
Acute kidney injury (AKI) arising from diverse etiologies is characterized by mitochondrial
dysfunction. The peroxisome proliferator-activated receptor γ coactivator-1alpha (PGC1α), a …
dysfunction. The peroxisome proliferator-activated receptor γ coactivator-1alpha (PGC1α), a …
Mitochondrial dysfunction and biogenesis in neurodegenerative diseases: pathogenesis and treatment
Neurodegenerative diseases are a heterogeneous group of disorders that are incurable and
characterized by the progressive degeneration of the function and structure of the central …
characterized by the progressive degeneration of the function and structure of the central …
[HTML][HTML] Antioxidant supplements and endurance exercise: Current evidence and mechanistic insights
Antioxidant supplements are commonly consumed by endurance athletes to minimize
exercise-induced oxidative stress, with the intention of enhancing recovery and improving …
exercise-induced oxidative stress, with the intention of enhancing recovery and improving …
Fiber types in mammalian skeletal muscles
Mammalian skeletal muscle comprises different fiber types, whose identity is first established
during embryonic development by intrinsic myogenic control mechanisms and is later …
during embryonic development by intrinsic myogenic control mechanisms and is later …
[HTML][HTML] Regulation of stem cell aging by metabolism and epigenetics
Stem cell aging and exhaustion are considered important drivers of organismal aging. Age-
associated declines in stem cell function are characterized by metabolic and epigenetic …
associated declines in stem cell function are characterized by metabolic and epigenetic …
[HTML][HTML] Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis
Mechanisms responsible for energy management in the cell and in the whole organism
require a complex network of transcription factors and cofactors. Peroxisome proliferator …
require a complex network of transcription factors and cofactors. Peroxisome proliferator …
Regulation of mitochondrial biogenesis
Although it is well established that physical activity increases mitochondrial content in
muscle, the molecular mechanisms underlying this process have only recently been …
muscle, the molecular mechanisms underlying this process have only recently been …