Although hydrophilic small molecule drugs are widely used in the clinic, their rapid
clearance, suboptimal biodistribution, low intracellular absorption and toxicity can limit their …

The pH-sensitive liposomes have been extensively used as an alternative to conventional
liposomes in effective intracellular delivery of therapeutics/antigen/DNA/diagnostics to …

In recent years, liposomes have been employed with growing success as pharmaceutical
carriers for antineoplastic drugs. One specific strategy used to enhance in vivo liposome …

Nanomedicine is emerging as a promising approach for diagnostic applications.
Nanoparticles are structures in the nanometer size range, which can present different …

Introduction: Despite remarkable advances in tumor treatment, many patients still die from
common tumors (breast, prostate, lung, CNS, colon, and pancreas), and thus, new …

Liposomes are lipid vesicles widely used as nanocarriers in targeted drug delivery systems
for therapeutic and/or diagnostic purposes. A strategy to prolong the blood circulation time of …

Irinotecan (IRN) is a semisynthetic derivative of camptothecin that acts as a topoisomerase I
inhibitor. IRN is used worldwide for the treatment of several types of cancer, including …

While small hydrophilic therapeutic molecules have proved to be exceptionally effective in
curing diseases, their in vivo efficacy remains low. Small molecule therapeutics infused in …

Despite efforts, cancer is still one of the leading causes of morbidity and mortality worldwide,
with approximately 14 million new cases and 8.2 million cancer-related deaths each year …

Purpose Therapeutic agents used in chemotherapy have low specificity leading to
undesired severe side effects. Hence, the development of drug delivery systems that …