Haplotype blocks and linkage disequilibrium in the human genome

JD Wall, JK Pritchard - Nature Reviews Genetics, 2003 - nature.com
There is great interest in the patterns and extent of linkage disequilibrium (LD) in humans
and other species. Characterizing LD is of central importance for gene-map** studies and …

From molecules to populations: appreciating and estimating recombination rate variation

JV Peñalba, JBW Wolf - Nature Reviews Genetics, 2020 - nature.com
Recombination is a central biological process with implications for many areas in the life
sciences. Yet we are only beginning to appreciate variation in the recombination rate along …

Haploview: analysis and visualization of LD and haplotype maps

JC Barrett, B Fry, J Maller, MJ Daly - Bioinformatics, 2005 - academic.oup.com
Research over the last few years has revealed significant haplotype structure in the human
genome. The characterization of these patterns, particularly in the context of medical genetic …

Modeling linkage disequilibrium and identifying recombination hotspots using single-nucleotide polymorphism data

N Li, M Stephens - Genetics, 2003 - academic.oup.com
We introduce a new statistical model for patterns of linkage disequilibrium (LD) among
multiple SNPs in a population sample. The model overcomes limitations of existing …

Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene

M Alarcón, BS Abrahams, JL Stone, JA Duvall… - The American Journal of …, 2008 - cell.com
Autism is a genetically complex neurodevelopmental syndrome in which language deficits
are a core feature. We describe results from two complimentary approaches used to identify …

[图书][B] Probability models for DNA sequence evolution

R Durrett, R Durrett - 2008 - Springer
Our basic question is: Given a collection of DNA sequences, what underlying forces are
responsible for the observed patterns of variability? To approach this question we introduce …

Cross‐cultural estimation of the human generation interval for use in genetics‐based population divergence studies

JN Fenner - American Journal of Physical Anthropology: The …, 2005 - Wiley Online Library
The length of the human generation interval is a key parameter when using genetics to date
population divergence events. However, no consensus exists regarding the generation …

A multiparent advanced generation inter‐cross population for genetic analysis in wheat

BE Huang, AW George, KL Forrest… - Plant biotechnology …, 2012 - Wiley Online Library
We present the first results from a novel multiparent advanced generation inter‐cross
(MAGIC) population derived from four elite wheat cultivars. The large size of this MAGIC …

Accounting for multiple comparisons in a genome-wide association study (GWAS)

RC Johnson, GW Nelson, JL Troyer, JA Lautenberger… - BMC genomics, 2010 - Springer
Background As we enter an era when testing millions of SNPs in a single gene association
study will become the standard, consideration of multiple comparisons is an essential part of …

Reconstructing patterns of reticulate evolution in plants

CR Linder, LH Rieseberg - American journal of botany, 2004 - Wiley Online Library
Until recently, rigorously reconstructing the many hybrid speciation events in plants has not
been practical because of the limited number of molecular markers available for plant …