Haplotype blocks and linkage disequilibrium in the human genome
There is great interest in the patterns and extent of linkage disequilibrium (LD) in humans
and other species. Characterizing LD is of central importance for gene-map** studies and …
and other species. Characterizing LD is of central importance for gene-map** studies and …
From molecules to populations: appreciating and estimating recombination rate variation
Recombination is a central biological process with implications for many areas in the life
sciences. Yet we are only beginning to appreciate variation in the recombination rate along …
sciences. Yet we are only beginning to appreciate variation in the recombination rate along …
Haploview: analysis and visualization of LD and haplotype maps
Research over the last few years has revealed significant haplotype structure in the human
genome. The characterization of these patterns, particularly in the context of medical genetic …
genome. The characterization of these patterns, particularly in the context of medical genetic …
Modeling linkage disequilibrium and identifying recombination hotspots using single-nucleotide polymorphism data
N Li, M Stephens - Genetics, 2003 - academic.oup.com
We introduce a new statistical model for patterns of linkage disequilibrium (LD) among
multiple SNPs in a population sample. The model overcomes limitations of existing …
multiple SNPs in a population sample. The model overcomes limitations of existing …
Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene
M Alarcón, BS Abrahams, JL Stone, JA Duvall… - The American Journal of …, 2008 - cell.com
Autism is a genetically complex neurodevelopmental syndrome in which language deficits
are a core feature. We describe results from two complimentary approaches used to identify …
are a core feature. We describe results from two complimentary approaches used to identify …
[图书][B] Probability models for DNA sequence evolution
R Durrett, R Durrett - 2008 - Springer
Our basic question is: Given a collection of DNA sequences, what underlying forces are
responsible for the observed patterns of variability? To approach this question we introduce …
responsible for the observed patterns of variability? To approach this question we introduce …
Cross‐cultural estimation of the human generation interval for use in genetics‐based population divergence studies
JN Fenner - American Journal of Physical Anthropology: The …, 2005 - Wiley Online Library
The length of the human generation interval is a key parameter when using genetics to date
population divergence events. However, no consensus exists regarding the generation …
population divergence events. However, no consensus exists regarding the generation …
A multiparent advanced generation inter‐cross population for genetic analysis in wheat
We present the first results from a novel multiparent advanced generation inter‐cross
(MAGIC) population derived from four elite wheat cultivars. The large size of this MAGIC …
(MAGIC) population derived from four elite wheat cultivars. The large size of this MAGIC …
Accounting for multiple comparisons in a genome-wide association study (GWAS)
RC Johnson, GW Nelson, JL Troyer, JA Lautenberger… - BMC genomics, 2010 - Springer
Background As we enter an era when testing millions of SNPs in a single gene association
study will become the standard, consideration of multiple comparisons is an essential part of …
study will become the standard, consideration of multiple comparisons is an essential part of …
Reconstructing patterns of reticulate evolution in plants
Until recently, rigorously reconstructing the many hybrid speciation events in plants has not
been practical because of the limited number of molecular markers available for plant …
been practical because of the limited number of molecular markers available for plant …