Genomic perspectives of transcriptional regulation in forebrain development
The forebrain is the seat of higher-order brain functions, and many human neuropsychiatric
disorders are due to genetic defects affecting forebrain development, making it imperative to …
disorders are due to genetic defects affecting forebrain development, making it imperative to …
Deciphering amyotrophic lateral sclerosis: what phenotype, neuropathology and genetics are telling us about pathogenesis
Amyotrophic lateral sclerosis (ALS) is characterized phenotypically by progressive
weakness and neuropathologically by loss of motor neurons. Phenotypically, there is …
weakness and neuropathologically by loss of motor neurons. Phenotypically, there is …
Transcriptional dysregulation of neocortical circuit assembly in ASD
KY Kwan - International review of neurobiology, 2013 - Elsevier
Autism spectrum disorders (ASDs) impair social cognition and communication, key higher-
order functions centered in the human neocortex. The assembly of neocortical circuitry is a …
order functions centered in the human neocortex. The assembly of neocortical circuitry is a …
Lmo4 establishes rostral motor cortex projection neuron subtype diversity
The mammalian neocortex is parcellated into anatomically and functionally distinct areas.
The establishment of area-specific neuronal diversity and circuit connectivity enables distinct …
The establishment of area-specific neuronal diversity and circuit connectivity enables distinct …
SnapShot: cortical development
http://dx.doi.org/ 10.1016/j.cell.2012.10.004 Page 1 1 Cell ???, ??MONTH?? ??DATE??, 200?
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Atypical neocortical development in the cited2 conditional knockout leads to behavioral deficits associated with neurodevelopmental disorders
NR Wagner, JL MacDonald - Neuroscience, 2021 - Elsevier
The mammalian neocortex develops from a single layer of neuroepithelial cells to form a six-
layer heterogeneous mosaic of differentiated neurons and glial cells. This process requires …
layer heterogeneous mosaic of differentiated neurons and glial cells. This process requires …
[HTML][HTML] Developmental markers expressed in neocortical layers are differentially exhibited in olfactory cortex
PC Brunjes, SK Osterberg - PLoS One, 2015 - journals.plos.org
Neurons in the cerebral cortex stratify on the basis of their time of origin, axonal terminations
and the molecular identities assigned during early development. Olfactory cortices share …
and the molecular identities assigned during early development. Olfactory cortices share …
Caveolin1 identifies a specific subpopulation of cerebral cortex callosal projection neurons (CPN) including dual projecting cortical callosal/frontal projection neurons …
The neocortex is composed of many distinct subtypes of neurons that must form precise
subtype-specific connections to enable the cortex to perform complex functions. Callosal …
subtype-specific connections to enable the cortex to perform complex functions. Callosal …
Developmental controls are re-expressed during induction of neurogenesis in the neocortex of young adult mice
US Sohur, P Arlotta, JD Macklis - Frontiers in neuroscience, 2012 - frontiersin.org
Whether induction of low-level neurogenesis in normally non-neurogenic regions of the
adult brain mimics aspects of developmental neurogenesis is currently unknown. Previously …
adult brain mimics aspects of developmental neurogenesis is currently unknown. Previously …
Molecular pathology, developmental changes and synaptic dysfunction in (pre-) symptomatic human C9ORF72-ALS/FTD cerebral organoids
AT van der Geest, CE Jakobs, T Ljubikj… - Acta neuropathologica …, 2024 - Springer
A hexanucleotide repeat expansion (HRE) in C9ORF72 is the most common genetic cause
of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Human brain …
of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Human brain …