Since optical coherence tomography (OCT) was first performed in humans two decades ago,
this imaging modality has been widely adopted in research on coronary atherosclerosis and …

Atherosclerotic Plaque Healing Atherosclerotic plaque rupture and erosion result in acute
coronary syndromes. Plaque healing after initial disruption has been less extensively …

Background Acute coronary syndrome and sudden cardiac death are often caused by
rupture and thrombosis of lipid-rich atherosclerotic coronary plaques (known as vulnerable …

Importance Coronary plaques that are prone to rupture and cause adverse cardiac events
are characterized by large plaque burden, large lipid content, and thin fibrous caps. Statins …

Over the last 3 decades there have been substantial improvements in treatments aimed at
reducing cardiovascular (CV) events. As these treatments have been developed, there have …

Atherosclerotic plaque results from a complex interplay between lipid deposition,
inflammatory changes, cell migration and arterial wall injury. Over the past two decades …

Despite advanced understanding of the biology of atherosclerosis, coronary heart disease
remains the leading cause of death worldwide. Progress has been challenging as half of the …

Artificial intelligence (AI) is likely to revolutionize the way medical images are analysed and
has the potential to improve the identification and analysis of vulnerable or high-risk …

Background: Complete revascularization with routine percutaneous coronary intervention of
nonculprit lesions after primary percutaneous coronary intervention improves outcomes in …

Prediction of the transition from stable to acute coronary syndromes driven by vascular
inflammation, thrombosis with subsequent microembolization, and vessel occlusion leading …