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[HTML][HTML] Engineering cytochrome P450 enzyme systems for biomedical and biotechnological applications
Cytochrome P450 enzymes (P450s) are broadly distributed among living organisms and
play crucial roles in natural product biosynthesis, degradation of xenobiotics, steroid …
play crucial roles in natural product biosynthesis, degradation of xenobiotics, steroid …
Vitamin D-mediated hypercalcemia: mechanisms, diagnosis, and treatment
Hypercalcemia occurs in up to 4% of the population in association with malignancy, primary
hyperparathyroidism, ingestion of excessive calcium and/or vitamin D, ectopic production of …
hyperparathyroidism, ingestion of excessive calcium and/or vitamin D, ectopic production of …
FDX1 can impact the prognosis and mediate the metabolism of lung adenocarcinoma
Background: Lung cancer has emerged as one of the most common cancers in recent years.
The mitochondrial electron transport chain (ETC) is closely connected with metabolic …
The mitochondrial electron transport chain (ETC) is closely connected with metabolic …
Mechanisms of cytochrome P450-catalyzed oxidations
Enzymes are complex biological catalysts and are critical to life. Most oxidations of
chemicals are catalyzed by cytochrome P450 (P450, CYP) enzymes, which generally utilize …
chemicals are catalyzed by cytochrome P450 (P450, CYP) enzymes, which generally utilize …
[HTML][HTML] Nuclear receptors, RXR, and the big bang
Isolation of genes encoding the receptors for steroids, retinoids, vitamin D, and thyroid
hormone and their structural and functional analysis revealed an evolutionarily conserved …
hormone and their structural and functional analysis revealed an evolutionarily conserved …
Recent structural insights into cytochrome P450 function
Cytochrome P450 (P450) enzymes are important in the metabolism of drugs, steroids, fat-
soluble vitamins, carcinogens, pesticides, and many other types of chemicals. Their catalytic …
soluble vitamins, carcinogens, pesticides, and many other types of chemicals. Their catalytic …
The biosynthesis of enzymatically oxidized lipids
Enzymatically oxidized lipids are a specific group of biomolecules that function as key
signaling mediators and hormones, regulating various cellular and physiological processes …
signaling mediators and hormones, regulating various cellular and physiological processes …
Heme enzyme structure and function
Metalloporphyrins are widely used throughout the biosphere, and of these heme (iron
protoporphyrin IX, Figure 1) is one of the most abundant and widely used. Heme shuttles …
protoporphyrin IX, Figure 1) is one of the most abundant and widely used. Heme shuttles …
Steroid hormone synthesis in mitochondria
Mitochondria are essential sites for steroid hormone biosynthesis. Mitochondria in the
steroidogenic cells of the adrenal, gonad, placenta and brain contain the cholesterol side …
steroidogenic cells of the adrenal, gonad, placenta and brain contain the cholesterol side …
Redox partners: function modulators of bacterial P450 enzymes
S Li, L Du, R Bernhardt - Trends in Microbiology, 2020 - cell.com
The superfamily of cytochrome P450 monooxygenases (P450s) is widespread in all
kingdoms of life. Functionally versatile P450s are extensively involved in diverse anabolic …
kingdoms of life. Functionally versatile P450s are extensively involved in diverse anabolic …