Revealing neuronal function through microelectrode array recordings
Microelectrode arrays and microprobes have been widely utilized to measure neuronal
activity, both in vitro and in vivo. The key advantage is the capability to record and stimulate …
activity, both in vitro and in vivo. The key advantage is the capability to record and stimulate …
3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics
Investigation of neural circuit dynamics is crucial for deciphering the functional connections
among regions of the brain and understanding the mechanism of brain dysfunction. Despite …
among regions of the brain and understanding the mechanism of brain dysfunction. Despite …
Production of human spinal-cord organoids recapitulating neural-tube morphogenesis
Human spinal-cord-like tissues induced from human pluripotent stem cells are typically
insufficiently mature and do not mimic the morphological features of neurulation. Here, we …
insufficiently mature and do not mimic the morphological features of neurulation. Here, we …
Towards building a more complex view of the lateral geniculate nucleus: Recent advances in understanding its role
The lateral geniculate nucleus (LGN) has often been treated in the past as a linear filter that
adds little to retinal processing of visual inputs. Here we review anatomical …
adds little to retinal processing of visual inputs. Here we review anatomical …
High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels
Studies on information processing and learning properties of neuronal networks would
benefit from simultaneous and parallel access to the activity of a large fraction of all neurons …
benefit from simultaneous and parallel access to the activity of a large fraction of all neurons …
Single-neuron bursts encode pathological oscillations in subcortical nuclei of patients with Parkinson's disease and essential tremor
Deep brain stimulation procedures offer an invaluable opportunity to study disease through
intracranial recordings from awake patients. Here, we address the relationship between …
intracranial recordings from awake patients. Here, we address the relationship between …
osl-dynamics, a toolbox for modeling fast dynamic brain activity
Neural activity contains rich spatiotemporal structure that corresponds to cognition. This
includes oscillatory bursting and dynamic activity that span across networks of brain regions …
includes oscillatory bursting and dynamic activity that span across networks of brain regions …
Mechanism-based rescue of Munc18-1 dysfunction in varied encephalopathies by chemical chaperones
NGL Guiberson, A Pineda, D Abramov, P Kharel… - Nature …, 2018 - nature.com
Heterozygous de novo mutations in the neuronal protein Munc18-1 are linked to epilepsies,
intellectual disability, movement disorders, and neurodegeneration. These devastating …
intellectual disability, movement disorders, and neurodegeneration. These devastating …
Electrophysiological phenotype characterization of human iPSC‐derived neuronal cell lines by means of high‐density microelectrode arrays
Recent advances in the field of cellular reprogramming have opened a route to studying the
fundamental mechanisms underlying common neurological disorders. High‐density …
fundamental mechanisms underlying common neurological disorders. High‐density …
Role of cerebellar GABAergic dysfunctions in the origins of essential tremor
Essential tremor (ET) is among the most prevalent movement disorders, but its origins are
elusive. The inferior olivary nucleus (ION) has been hypothesized as the prime generator of …
elusive. The inferior olivary nucleus (ION) has been hypothesized as the prime generator of …