Aliphatic three-and four-membered rings including cyclopropanes, cyclobutanes, oxetanes,
azetidines and bicyclo [1.1. 1] pentanes have been increasingly exploited in medicinal …

Ferroptosis is a form of regulated necrosis associated with the iron-dependent accumulation
of lipid hydroperoxides that may play a key role in the pathogenesis of degenerative …

Unmitigated UV radiation (UVR) induces skin photoaging and multiple forms of cutaneous
carcinoma by complex pathways that include those mediated by UV-induced reactive …

The key role of antioxidants in treating and preventing many systemic and topical diseases
is well recognized. One of the most potent antioxidants available for pharmaceutical and …

The poor regioselectivity of the [4+ 2] cycloaddition of 3-azetidinones with internal alkynes
bearing two alkyl substituents via nickel-catalyzed carbon–carbon activation is addressed …

Reverse aldol opening renders amides of 3-hydroxyazetidinecarboxylic acids (3-OH-Aze)
unstable above pH 8. Aze, found in sugar beet, is mis-incorporated for proline in peptides in …

Introduction Our laboratories have demonstrated that accumulation of oligomeric amyloid β
(OAβ) in neurons is an essential step leading to OAβ-mediated mitochondrial dysfunction …

Mitochondrial dysfunction, characterized by the electron transport chain (ETC) leakage and
reduced adenosine tri-phosphate synthesis, occurs primarily due to free radicals-induced …

An efficient and practical strategy for the synthesis of unknown azetidine iminosugars (2 S,
3R, 4S)-2-((R)-1, 2-dihydroxyethyl)-3-hydroxy-4-(hydroxymethyl) azetidine 2,(2S, 3r, 4R)-3 …

Previously we described a novel series of pyrimidinol antioxidants and their structural
optimization as potential therapeutic agents for neurodegenerative and mitochondrial …