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MicroRNA biomarkers and platelet reactivity: the clot thickens
N Sunderland, P Skroblin, T Barwari… - Circulation …, 2017 - ahajournals.org
Over the last few years, several groups have evaluated the potential of microRNAs
(miRNAs) as biomarkers for cardiometabolic disease. In this review, we discuss the …
(miRNAs) as biomarkers for cardiometabolic disease. In this review, we discuss the …
Megakaryocyte and platelet transcriptomics for discoveries in human health and disease
P Davizon-Castillo, JW Rowley… - … thrombosis, and vascular …, 2020 - ahajournals.org
Anucleate platelets, long viewed as merely cell fragments with a limited repertoire of rapid-
acting hemostatic functions, are now recognized to have a complex and dynamic …
acting hemostatic functions, are now recognized to have a complex and dynamic …
[HTML][HTML] Platelets contribute to disease severity in COVID‐19
Objective Heightened inflammation, dysregulated immunity, and thrombotic events are
characteristic of hospitalized COVID‐19 patients. Given that platelets are key regulators of …
characteristic of hospitalized COVID‐19 patients. Given that platelets are key regulators of …
[HTML][HTML] Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease
T Petzold, Z Zhang, I Ballesteros, I Saleh, A Polzin… - Immunity, 2022 - cell.com
Intravascular neutrophils and platelets collaborate in maintaining host integrity, but their
interaction can also trigger thrombotic complications. We report here that cooperation …
interaction can also trigger thrombotic complications. We report here that cooperation …
Reticulated platelets and immature platelet fraction: Clinical applications and method limitations
M Buttarello, G Mezzapelle, F Freguglia… - … Journal of Laboratory …, 2020 - Wiley Online Library
Abstract So‐called “reticulated” or “immature platelets,” which are newly released into the
circulation, are more reactive than mature platelets, contain more RNA, and can be counted …
circulation, are more reactive than mature platelets, contain more RNA, and can be counted …
Effects of P2Y12 receptor antagonists beyond platelet inhibition – comparison of ticagrelor with thienopyridines
S Nylander, R Schulz - British journal of pharmacology, 2016 - Wiley Online Library
The effect and clinical benefit of P2Y12 receptor antagonists may not be limited to platelet
inhibition and the prevention of arterial thrombus formation. Potential additional effects …
inhibition and the prevention of arterial thrombus formation. Potential additional effects …
Novel biomarkers for diagnosis and monitoring of immune thrombocytopenia
Lower-than-normal platelet counts are a hallmark of the acquired autoimmune illness known
as immune thrombocytopenia, which can affect both adults and children. Immune …
as immune thrombocytopenia, which can affect both adults and children. Immune …
Transcriptome analysis of reticulated platelets reveals a prothrombotic profile
Reticulated platelets (RPs) are larger, hyperreactive platelets that contain significantly more
ribonucleic acid (RNA) compared with mature platelets (MPs). High levels of RPs in …
ribonucleic acid (RNA) compared with mature platelets (MPs). High levels of RPs in …
Role of reticulated platelets in cardiovascular disease
D Bongiovanni, J Han, M Klug, K Kirmes… - … and Vascular Biology, 2022 - ahajournals.org
Human platelets differ considerably with regard to their size, RNA content and
thrombogenicity. Reticulated platelets (RPs) are young, hyper-reactive platelets that are …
thrombogenicity. Reticulated platelets (RPs) are young, hyper-reactive platelets that are …
[HTML][HTML] Ultrastructural, transcriptional, and functional differences between human reticulated and non‐reticulated platelets
Background Reticulated platelets (RP) are the youngest circulating platelets in blood. An
increased amount of this subpopulation is associated with higher cardiovascular risk and …
increased amount of this subpopulation is associated with higher cardiovascular risk and …