MicroRNA biomarkers and platelet reactivity: the clot thickens

N Sunderland, P Skroblin, T Barwari… - Circulation …, 2017 - ahajournals.org
Over the last few years, several groups have evaluated the potential of microRNAs
(miRNAs) as biomarkers for cardiometabolic disease. In this review, we discuss the …

Megakaryocyte and platelet transcriptomics for discoveries in human health and disease

P Davizon-Castillo, JW Rowley… - … thrombosis, and vascular …, 2020 - ahajournals.org
Anucleate platelets, long viewed as merely cell fragments with a limited repertoire of rapid-
acting hemostatic functions, are now recognized to have a complex and dynamic …

[HTML][HTML] Platelets contribute to disease severity in COVID‐19

TJ Barrett, S Bilaloglu, M Cornwell, HM Burgess… - Journal of Thrombosis …, 2021 - Elsevier
Objective Heightened inflammation, dysregulated immunity, and thrombotic events are
characteristic of hospitalized COVID‐19 patients. Given that platelets are key regulators of …

[HTML][HTML] Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease

T Petzold, Z Zhang, I Ballesteros, I Saleh, A Polzin… - Immunity, 2022 - cell.com
Intravascular neutrophils and platelets collaborate in maintaining host integrity, but their
interaction can also trigger thrombotic complications. We report here that cooperation …

Reticulated platelets and immature platelet fraction: Clinical applications and method limitations

M Buttarello, G Mezzapelle, F Freguglia… - … Journal of Laboratory …, 2020 - Wiley Online Library
Abstract So‐called “reticulated” or “immature platelets,” which are newly released into the
circulation, are more reactive than mature platelets, contain more RNA, and can be counted …

Effects of P2Y12 receptor antagonists beyond platelet inhibition – comparison of ticagrelor with thienopyridines

S Nylander, R Schulz - British journal of pharmacology, 2016 - Wiley Online Library
The effect and clinical benefit of P2Y12 receptor antagonists may not be limited to platelet
inhibition and the prevention of arterial thrombus formation. Potential additional effects …

Novel biomarkers for diagnosis and monitoring of immune thrombocytopenia

A Allegra, N Cicero, G Mirabile, CM Giorgianni… - International journal of …, 2023 - mdpi.com
Lower-than-normal platelet counts are a hallmark of the acquired autoimmune illness known
as immune thrombocytopenia, which can affect both adults and children. Immune …

Transcriptome analysis of reticulated platelets reveals a prothrombotic profile

D Bongiovanni, G Santamaria, M Klug… - Thrombosis and …, 2019 - thieme-connect.com
Reticulated platelets (RPs) are larger, hyperreactive platelets that contain significantly more
ribonucleic acid (RNA) compared with mature platelets (MPs). High levels of RPs in …

Role of reticulated platelets in cardiovascular disease

D Bongiovanni, J Han, M Klug, K Kirmes… - … and Vascular Biology, 2022 - ahajournals.org
Human platelets differ considerably with regard to their size, RNA content and
thrombogenicity. Reticulated platelets (RPs) are young, hyper-reactive platelets that are …

[HTML][HTML] Ultrastructural, transcriptional, and functional differences between human reticulated and non‐reticulated platelets

L Hille, M Lenz, A Vlachos, B Grüning, L Hein… - Journal of Thrombosis …, 2020 - Elsevier
Background Reticulated platelets (RP) are the youngest circulating platelets in blood. An
increased amount of this subpopulation is associated with higher cardiovascular risk and …