From the very early days of nuclear factor‐κB (NF‐κB) research, it was recognized that
different protein kinase C (PKC) isoforms might be involved in the activation of NF‐κB …

The relevance of potentially reversible post-translational modifications required for
controlling cellular processes in cancer is one of the most thriving arenas of cellular and …

The mTORC1 complex is central to the cellular response to changes in nutrient availability.
The signaling adaptor p62 contributes to mTORC1 activation in response to amino acids …

PKCε, an oncogenic member of the PKC family, is aberrantly overexpressed in epithelial
cancers. To date, little is known about functional interactions of PKCε with other genetic …

The pro-oncogenic kinase PKCε is overexpressed in human prostate cancer and cooperates
with loss of the tumor suppressor Pten for the development of prostatic adenocarcinoma …

Protein kinase C ϵ (PKCϵ) has emerged as an oncogenic kinase and plays important roles
in cell survival, mitogenesis and invasion. PKCϵ is up-regulated in most epithelial cancers …

The overwhelming number of genetic alterations identified through cancer genome
sequencing requires complementary approaches to interpret their significance and …

More than 15 years ago, the first generation of genetically engineered mouse (GEM) models
of prostate cancer was introduced. These transgenic models utilized prostate-specific …

The tumor suppressor prostate apoptosis response-4 (Par-4) has recently turned 'twenty-
five'. Beyond its indisputable role as an apoptosis inducer, an increasing and sometimes …

Studies showing reduced PKCζ expression or enzymatic activity in different types of human
cancers support the clinical relevance of PKCζ as a tumor suppressor. However, the in vivo …