Chemokines and cytokines are critical for initiating and coordinating the organized and
sequential recruitment and activation of cells into Mycobacterium tuberculosis-infected …

Abstract Treatment of tuberculosis (TB) involves the administration of anti-mycobacterial
drugs for several months. The emergence of drug-resistant strains of Mycobacterium …

Immune responses to Mycobacterium tuberculosis are only partially effective; they drive the
bacteria into a latent state, but rarely eliminate them. Unfortunately, the latent state of M …

Abstract Interleukin 1 (IL-1) is an important mediator of innate immunity but can also promote
inflammatory tissue damage. During chronic infections such as tuberculosis, the beneficial …

Tuberculosis is the leading cause of death by an infectious disease worldwide. However, the
involvement of innate lymphoid cells (ILCs) in immune responses to infection with …

Activation of the DNA-dependent cytosolic surveillance pathway in response to
Mycobacterium tuberculosis infection stimulates ubiquitin-dependent autophagy and …

Neutrophil accumulation is associated with lung pathology during active tuberculosis (ATB).
However, the molecular mechanism or mechanisms by which neutrophils accumulate in the …

The dual burden of tuberculosis (TB) and diabetes has attracted much attention in the past
decade as diabetes prevalence has increased dramatically in countries already afflicted with …

Pulmonary cavities, the hallmark of tuberculosis (TB), are characterized by high
mycobacterial load and perpetuate the spread of M. tuberculosis. The mechanism of matrix …

Successful host defense against numerous pulmonary infections depends on bacterial
clearance by polymorphonuclear leukocytes (PMNs); however, excessive PMN …