Analysis of aptamer discovery and technology
Aptamers are nucleic acid molecules that mimic antibodies by folding into complex 3D
shapes that bind to specific targets. Although some aptamers exist naturally as the ligand …
shapes that bind to specific targets. Although some aptamers exist naturally as the ligand …
In vitro selection of aptamers and their applications
The introduction of the in vitro evolution method known as SELEX (systematic evolution of
ligands by exponential enrichment) more than 30 years ago led to the conception of …
ligands by exponential enrichment) more than 30 years ago led to the conception of …
Towards microfluidic-based exosome isolation and detection for tumor therapy
Exosomes are a class of cell-secreted, nano-sized extracellular vesicles with a bilayer
membrane structure of 30–150 nm in diameter. Their discovery and application have …
membrane structure of 30–150 nm in diameter. Their discovery and application have …
Biomolecular sensors for advanced physiological monitoring
Body-based biomolecular sensing systems, including wearable, implantable and
consumable sensors allow comprehensive health-related monitoring. Glucose sensors have …
consumable sensors allow comprehensive health-related monitoring. Glucose sensors have …
[HTML][HTML] Current perspectives on aptamers as diagnostic tools and therapeutic agents
Aptamers are synthetic single-stranded DNA or RNA sequences selected from combinatorial
oligonucleotide libraries through the well-known in vitro selection and iteration process …
oligonucleotide libraries through the well-known in vitro selection and iteration process …
Advances in analysis and detection of major mycotoxins in foods
Mycotoxins are the most widely studied biological toxins, which contaminate foods at very
low concentrations. This review describes the emerging extraction techniques and the …
low concentrations. This review describes the emerging extraction techniques and the …
Machine learning guided aptamer refinement and discovery
Aptamers are single-stranded nucleic acid ligands that bind to target molecules with high
affinity and specificity. They are typically discovered by searching large libraries for …
affinity and specificity. They are typically discovered by searching large libraries for …
Selection of aptamers for sensing caffeine and discrimination of its three single demethylated analogues
With the growing consumption of caffeine-containing beverages, detection of caffeine has
become an important biomedical, bioanalytical, and environmental topic. We herein isolated …
become an important biomedical, bioanalytical, and environmental topic. We herein isolated …
Directed evolution of aptamer discovery technologies
D Wu, CKL Gordon, JH Shin… - Accounts of Chemical …, 2022 - ACS Publications
Conspectus Although antibodies are a powerful tool for molecular biology and clinical
diagnostics, there are many emerging applications for which nucleic acid-based aptamers …
diagnostics, there are many emerging applications for which nucleic acid-based aptamers …
Nucleic acid aptamer-based methods for diagnosis of infections
KS Park - Biosensors and Bioelectronics, 2018 - Elsevier
Infectious diseases are a serious global problem, which not only take an enormous human
toll but also incur tremendous economic losses. In combating infectious diseases, rapid and …
toll but also incur tremendous economic losses. In combating infectious diseases, rapid and …