Analysis of aptamer discovery and technology

MR Dunn, RM Jimenez, JC Chaput - Nature Reviews Chemistry, 2017 - nature.com
Aptamers are nucleic acid molecules that mimic antibodies by folding into complex 3D
shapes that bind to specific targets. Although some aptamers exist naturally as the ligand …

In vitro selection of aptamers and their applications

MC DeRosa, A Lin, P Mallikaratchy… - Nature Reviews …, 2023 - nature.com
The introduction of the in vitro evolution method known as SELEX (systematic evolution of
ligands by exponential enrichment) more than 30 years ago led to the conception of …

Towards microfluidic-based exosome isolation and detection for tumor therapy

J Wang, P Ma, DH Kim, BF Liu, U Demirci - Nano Today, 2021 - Elsevier
Exosomes are a class of cell-secreted, nano-sized extracellular vesicles with a bilayer
membrane structure of 30–150 nm in diameter. Their discovery and application have …

Biomolecular sensors for advanced physiological monitoring

CD Flynn, D Chang, A Mahmud, H Yousefi… - Nature Reviews …, 2023 - nature.com
Body-based biomolecular sensing systems, including wearable, implantable and
consumable sensors allow comprehensive health-related monitoring. Glucose sensors have …

[HTML][HTML] Current perspectives on aptamers as diagnostic tools and therapeutic agents

P Kumar Kulabhusan, B Hussain, M Yüce - Pharmaceutics, 2020 - mdpi.com
Aptamers are synthetic single-stranded DNA or RNA sequences selected from combinatorial
oligonucleotide libraries through the well-known in vitro selection and iteration process …

Advances in analysis and detection of major mycotoxins in foods

S Agriopoulou, E Stamatelopoulou, T Varzakas - Foods, 2020 - mdpi.com
Mycotoxins are the most widely studied biological toxins, which contaminate foods at very
low concentrations. This review describes the emerging extraction techniques and the …

Machine learning guided aptamer refinement and discovery

A Bashir, Q Yang, J Wang, S Hoyer, W Chou… - Nature …, 2021 - nature.com
Aptamers are single-stranded nucleic acid ligands that bind to target molecules with high
affinity and specificity. They are typically discovered by searching large libraries for …

Selection of aptamers for sensing caffeine and discrimination of its three single demethylated analogues

PJJ Huang, J Liu - Analytical Chemistry, 2022 - ACS Publications
With the growing consumption of caffeine-containing beverages, detection of caffeine has
become an important biomedical, bioanalytical, and environmental topic. We herein isolated …

Directed evolution of aptamer discovery technologies

D Wu, CKL Gordon, JH Shin… - Accounts of Chemical …, 2022 - ACS Publications
Conspectus Although antibodies are a powerful tool for molecular biology and clinical
diagnostics, there are many emerging applications for which nucleic acid-based aptamers …

Nucleic acid aptamer-based methods for diagnosis of infections

KS Park - Biosensors and Bioelectronics, 2018 - Elsevier
Infectious diseases are a serious global problem, which not only take an enormous human
toll but also incur tremendous economic losses. In combating infectious diseases, rapid and …