Immunometabolism is a burgeoning field of research that investigates how immune cells
harness nutrients to drive their growth and functions. Myeloid cells play a pivotal role in …

Macrophages are present at high frequency in most solid tumor types, and their relative
abundance negatively correlates with therapy responses and survival outcomes. Tissue …

The ecosystem of brain tumors is considered immunosuppressed, but our current
knowledge may be incomplete. Here we analyzed clinical cell and tissue specimens derived …

Glioblastoma is a Grade 4 primary brain tumor defined by therapy resistance, diffuse
infiltration, and near-uniform lethality. The underlying mechanisms are unknown, and no …

The current median survival for glioblastoma (GBM) patients is only about 16 months, with
many patients succumbing to the disease in just a matter of months, making it the most …

Simple Summary The mesenchymal (MES) phenotype of glioblastoma (GBM) confers
resistance to various therapeutic strategies and results from both tumor-intrinsic genetic …

Metabolic flexibility is key for the function of myeloid cells. Arginine metabolism is integral to
the regulation of myeloid cell responses. Nitric oxide (NO) production from arginine is vital …

The glioblastoma tumour microenvironment is characterised by immense heterogeneity, with
malignant and non-malignant cells that interact in a complex ecosystem. Emerging evidence …

Glioblastoma (GBM) is the most aggressive brain tumor for which current therapies have
limited efficacy. Immunosuppression and difficulties in accessing tumors with therapeutic …

Recently, RIT1 has been implicated in a range of neurological disorders; however, its
precise function in glioma pathogenesis is not yet well‐defined. This study employed …