Multidimensional analyses have demonstrated the presence of a unique tumor
microenvironment (TME) in liver cancer. Tumor‐associated macrophages (TAMs) are …

The anti-tumor activity of the immune system is increasingly recognized as critical for the
mounting of a prolonged and effective response to cancer growth and invasion, and for …

Background Trastuzumab is a first‐line targeted therapy for human epidermal growth factor
receptor‐2 (HER2)‐positive gastric cancer. However, the inevitable occurrence of acquired …

Advances in immunotherapy have revolutionized the treatment of multiple cancers.
Unfortunately, tumors usually have impaired blood perfusion, which limits the delivery of …

Quantitative systems pharmacology (QSP) models and spatial agent-based models (ABM)
are powerful and efficient approaches for the analysis of biological systems and for clinical …

The tumor microenvironment (TME) is a highly complex environment that surrounds tumors.
Interactions between cancer cells/non-cancerous cells and cells/non-cell components in the …

Within the tumor microenvironment, macrophages exist in an immunosuppressive state,
preventing T cells from eliminating the tumor. Due to this, research is focusing on …

The tumor microenvironment (TME) plays a central role in regulating antitumor immune
responses. As an important part of the TME, alternatively activated type 2 (M2) macrophages …

Drug development in oncology commonly exploits the tools of molecular biology to gain
therapeutic benefit through reprograming of cellular responses. In immuno‐oncology (IO) …

Tumors are not merely cancerous cells that undergo mindless proliferation. Rather, they are
highly organized and interconnected organ systems. Tumor cells reside in complex …