Reconstructing organisms in silico: genome-scale models and their emerging applications

X Fang, CJ Lloyd, BO Palsson - Nature Reviews Microbiology, 2020 - nature.com
Escherichia coli is considered to be the best-known microorganism given the large number
of published studies detailing its genes, its genome and the biochemical functions of its …

The role of the gut microbiota in colorectal cancer causation

EA Alhinai, GE Walton, DM Commane - International Journal of Molecular …, 2019 - mdpi.com
Here, we reviewed emerging evidence on the role of the microbial community in colorectal
carcinogenesis. A healthy gut microbiota promotes intestinal homeostasis and can exert anti …

Genome-scale metabolic modeling of the human microbiome in the era of personalized medicine

A Heinken, A Basile, J Hertel… - Annual review of …, 2021 - annualreviews.org
The human microbiome plays an important role in human health and disease. Meta-omics
analyses provide indispensable data for linking changes in microbiome composition and …

A biochemically-interpretable machine learning classifier for microbial GWAS

ES Kavvas, L Yang, JM Monk, D Heckmann… - Nature …, 2020 - nature.com
Current machine learning classifiers have successfully been applied to whole-genome
sequencing data to identify genetic determinants of antimicrobial resistance (AMR), but they …

A workflow for generating multi-strain genome-scale metabolic models of prokaryotes

CJ Norsigian, X Fang, Y Seif, JM Monk, BO Palsson - Nature protocols, 2020 - nature.com
Genome-scale models (GEMs) of bacterial strains' metabolism have been formulated and
used over the past 20 years. Recently, with the number of genome sequences exponentially …

The effects of diet and gut microbiota on the regulation of intestinal mucin glycosylation

D Qu, G Wang, L Yu, F Tian, W Chen, Q Zhai - Carbohydrate polymers, 2021 - Elsevier
Intestinal mucins glycosylation is regulated by host cues and environmental signals from the
microbiome and diets. However, the mechanisms responsible for the dialogue between …